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Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

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Title: Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.
Authors: A M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Wang G; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Institute of Modern Biology, Nanjing University, Nanjing, China., Zammit NW; Department of Immunology, Harvard Medical School, Boston, MA, USA., Roth L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Maierhaba Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Bogoslavski D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Cai C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Langston PK; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA., Zhang Q; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Afonina IS; VIB Center for Inflammation Research, Gent, Belgium.; UGent Department of Biomedical Molecular Biology, Gent, Belgium., Beyaert R; VIB Center for Inflammation Research, Gent, Belgium.; UGent Department of Biomedical Molecular Biology, Gent, Belgium., Spiegelman BM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu., Mathis D; Department of Immunology, Harvard Medical School, Boston, MA, USA. dm@hms.harvard.edu.
Source: Nature metabolism [Nat Metab] 2026 Apr; Vol. 8 (4), pp. 885-901. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.
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  Data: <searchLink fieldCode="AU" term="%22A+M%22">A M</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Institute of Modern Biology, Nanjing University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zammit+NW%22">Zammit NW</searchLink>; Department of Immunology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roth+L%22">Roth L</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maierhaba+Y%22">Maierhaba Y</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bogoslavski+D%22">Bogoslavski D</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+C%22">Cai C</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Langston+PK%22">Langston PK</searchLink>; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Afonina+IS%22">Afonina IS</searchLink>; VIB Center for Inflammation Research, Gent, Belgium.; UGent Department of Biomedical Molecular Biology, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Beyaert+R%22">Beyaert R</searchLink>; VIB Center for Inflammation Research, Gent, Belgium.; UGent Department of Biomedical Molecular Biology, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Spiegelman+BM%22">Spiegelman BM</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Mathis+D%22">Mathis D</searchLink>; Department of Immunology, Harvard Medical School, Boston, MA, USA. dm@hms.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2026 Apr; Vol. 8 (4), pp. 885-901. <i>Date of Electronic Publication: </i>2026 Apr 03.
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