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Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation.

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Title: Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation.
Authors: Park DH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Ahn SY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Kim J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Choi J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Lee S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Kang M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Song JM; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea., Suh YH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea. suhyho@snu.ac.kr.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea. suhyho@snu.ac.kr.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea. suhyho@snu.ac.kr.
Source: EMBO reports [EMBO Rep] 2026 May; Vol. 27 (10), pp. 2749-2771. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation.
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  Data: <searchLink fieldCode="AU" term="%22Park+DH%22">Park DH</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Ahn+SY%22">Ahn SY</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Song+JM%22">Song JM</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Suh+YH%22">Suh YH</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea. suhyho@snu.ac.kr.; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea. suhyho@snu.ac.kr.; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul, South Korea. suhyho@snu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 May; Vol. 27 (10), pp. 2749-2771. <i>Date of Electronic Publication: </i>2026 Apr 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100963049 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-3178 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221469221X%22">1469221X </searchLink><i>NLM ISO Abbreviation: </i>EMBO Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44319-026-00766-9
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              Text: 2026 May
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