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Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.

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Title: Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.
Authors: Mbah NE; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Sutton D; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Hong HS; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA., Singhal R; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Menjivar RE; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Perricone MD; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA., Giza H; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Myers AL; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Nwosu ZC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Alektiar JM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Lin J; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Long D; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Andren AC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Frankel TL; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Pasca di Magliano M; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Franchi L; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA., Shah YM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.
Source: Cancer & metabolism [Cancer Metab] 2026 Apr 04; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.
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  Data: <searchLink fieldCode="AU" term="%22Mbah+NE%22">Mbah NE</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+D%22">Sutton D</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hong+HS%22">Hong HS</searchLink>; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Singhal+R%22">Singhal R</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Menjivar+RE%22">Menjivar RE</searchLink>; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Perricone+MD%22">Perricone MD</searchLink>; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Giza+H%22">Giza H</searchLink>; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sajjakulnukit+P%22">Sajjakulnukit P</searchLink>; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Myers+AL%22">Myers AL</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nwosu+ZC%22">Nwosu ZC</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Alektiar+JM%22">Alektiar JM</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Long+D%22">Long D</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Andren+AC%22">Andren AC</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+HC%22">Crawford HC</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Frankel+TL%22">Frankel TL</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pasca+di+Magliano+M%22">Pasca di Magliano M</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Franchi+L%22">Franchi L</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA.<br /><searchLink fieldCode="AU" term="%22Shah+YM%22">Shah YM</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lyssiotis+CA%22">Lyssiotis CA</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.; Rogel and Blondy Center for Pancreatic Cancer, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@umich.edu.
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  Data: <searchLink fieldCode="JN" term="%22101607582%22">Cancer & metabolism</searchLink> [Cancer Metab] 2026 Apr 04; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Apr 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101607582 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2049-3002 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220493002%22">20493002 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Metab <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s40170-026-00428-3
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