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Porphyromonas gingivalis outer membrane vesicles promote alveolar bone resorption by increasing the local RANKL/OPG ratio in experimental periodontitis model rats.

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Title: Porphyromonas gingivalis outer membrane vesicles promote alveolar bone resorption by increasing the local RANKL/OPG ratio in experimental periodontitis model rats.
Authors: Nakamura D; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan., Inagaki Y; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan. yinazo@tokushima-u.ac.jp., Uemura Y; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan., Hiroshima Y; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan., Iwata Y; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan., Kido R; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan., Bando M; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan., Sumitomo T; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan., Yumoto H; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.
Source: Scientific reports [Sci Rep] 2026 Apr 05; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
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  Data: Porphyromonas gingivalis outer membrane vesicles promote alveolar bone resorption by increasing the local RANKL/OPG ratio in experimental periodontitis model rats.
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  Data: <searchLink fieldCode="AU" term="%22Nakamura+D%22">Nakamura D</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.<br /><searchLink fieldCode="AU" term="%22Inagaki+Y%22">Inagaki Y</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan. yinazo@tokushima-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Uemura+Y%22">Uemura Y</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.<br /><searchLink fieldCode="AU" term="%22Hiroshima+Y%22">Hiroshima Y</searchLink>; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.<br /><searchLink fieldCode="AU" term="%22Iwata+Y%22">Iwata Y</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.<br /><searchLink fieldCode="AU" term="%22Kido+R%22">Kido R</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.<br /><searchLink fieldCode="AU" term="%22Bando+M%22">Bando M</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.<br /><searchLink fieldCode="AU" term="%22Sumitomo+T%22">Sumitomo T</searchLink>; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.<br /><searchLink fieldCode="AU" term="%22Yumoto+H%22">Yumoto H</searchLink>; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770- 8504, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Apr 05; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Apr 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE; In Process
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              Text: 2026 Apr 05
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