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Efficacy and Safety of First-Line Ramucirumab Plus Erlotinib for EGFR L858R-Mutated NSCLC in Real-World Practice: A Retrospective Multicenter REAL-SPEED Analysis.

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Title: Efficacy and Safety of First-Line Ramucirumab Plus Erlotinib for EGFR L858R-Mutated NSCLC in Real-World Practice: A Retrospective Multicenter REAL-SPEED Analysis.
Authors: Ishihara M; Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan., Kawamura T; Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan., Namba Y; Department of Respiratory Medicine, Juntendo University Urayasu Hospital, Chiba, Japan., Takeyasu Y; Department of Thoracic Oncology, Kansai Medical University, Osaka, Japan., Hasegawa Y; Department of Respiratory Medicine, Aomori Prefectural Central Hospital, Aomori, Japan., Sato Y; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan., Negi Y; Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Hyogo, Japan., Oba T; Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, Japan., Sumi T; Department of Respiratory Medicine, Hakodate Goryoukaku Hospital, Hokkaido, Japan., Hirata H; Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University, Saitama Medical Center, Saitama, Japan., Funabashi H; Division of Respiratory Medicine, Department of Internal Medicine, Matsudo City General Hospital, Chiba, Japan., Oya Y; Department of Respiratory Medicine & Clinical Allergy, Fujita Health University, Aichi, Japan., Kikuchi H; Department of Respiratory Medicine, Obihiro-Kousei General Hospital, Hokkaido, Japan., Tachihara M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan., Nakatani T; Department of Respiratory Medicine, Osaka Police Hospital, Osaka, Japan., Harada T; Department of Medical Oncology, Fukuchiyama City Hospital, Kyoto, Japan., Tanimura K; Department of Medical Oncology, Fukuchiyama City Hospital, Kyoto, Japan., Nakagawa T; Department of Thoracic Surgery, Omagari Kosei Medical Center, Akita, Japan., Takeda N; Department of Respiratory Medicine, Kariya Toyota General Hospital, Aichi, Japan., Asami T; Department of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan., Honjo O; Department of Respiratory Medicine, Sapporo Minami-Sanjo Hospital, Hokkaido, Japan., Nagashima H; Division of Pulmonary Medicine, Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan., Yamaura T; Department of Thoracic Surgery, Takeda General Hospital, Fukushima, Japan., Hata N; Department of Respiratory Medicine, Kawaguchi Municipal Medical Center, Saitama, Japan., Kitazono M; Department of Respiratory Medicine and Oncology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan., Nishioka N; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tamiya A; Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Sakamori Y; Department of Respiratory Medicine, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan., Shigaki R; Division of Respiratory Medicine and Neurology, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan., Kaira K; Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Saitama, Japan., Honda R; Department of Respiratory Medicine, Asahi General Hospital, Chiba, Japan., Matsui T; Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hosipital, Shizuoka, Japan., Suzuki E; Division of Thoracic Surgery, Respiratory Disease Center, Seirei Mikatahara General Hospital, Shizuoka, Japan., Ito K; Respiratory Center, Matsusaka Municipal Hospital, Mie, Japan., Otsuka K; Department of Respiratory Medicine, Shinko Hospital, Hyogo, Japan., Yoshizumi Y; Department of Respiratory Medicine, Takarazuka City Hospital, Hyogo, Japan., Murakami Y; Department of Respiratory Medicine, National Hospital Organization Wakayama Hospital, Wakayama, Japan., Matsuno K; Department of Respiratory Medicine, Naha City Hospital, Okinawa, Japan., Inoue S; Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan., Kisohara A; Department of Respiratory Medicine, Kasukabe Medical Center, Saitama, Japan., Kusumoto S; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan., Aoshima H; Department of Thoracic Surgery, Tokyo Women's Medical University, Tokyo, Japan., Kakizaki Y; Lung Cancer and Respiratory Disease Center, Yamanashi Prefectural Central Hospital, Yamanashi, Japan., Kubo A; Department of Respiratory Medicine and Allergology, Aichi Medical University, Aichi, Japan., Hata A; Division of Thoracic Oncology, Kobe Minimally Invasive Cancer Center, Hyogo, Japan., Ishikawa N; Department of Respiratory Medicine, Hiroshima Prefectural Hospital, Hiroshima, Japan., Hamai K; Department of Respiratory Medicine, JA Onomichi General Hospital, Hiroshima, Japan., Kanaji N; Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan., Mamesaya N; Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan., Misumi T; Department of Data Science, National Cancer Center Hospital East, Chiba, Japan., Matsutani N; Department of Thoracic Surgery, Shin-Yurigaoka General Hospital, Kanagawa, Japan., Seki N; Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Source: JTO clinical and research reports [JTO Clin Res Rep] 2026 Feb 12; Vol. 7 (4), pp. 100972. Date of Electronic Publication: 2026 Feb 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101769967 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3643 (Electronic) Linking ISSN: 26663643 NLM ISO Abbreviation: JTO Clin Res Rep Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and Safety of First-Line Ramucirumab Plus Erlotinib for EGFR L858R-Mutated NSCLC in Real-World Practice: A Retrospective Multicenter REAL-SPEED Analysis.
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Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Oba+T%22">Oba T</searchLink>; Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Sumi+T%22">Sumi T</searchLink>; Department of Respiratory Medicine, Hakodate Goryoukaku Hospital, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+H%22">Hirata H</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University, Saitama Medical Center, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Funabashi+H%22">Funabashi H</searchLink>; Division of Respiratory Medicine, Department of Internal Medicine, Matsudo City General Hospital, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Oya+Y%22">Oya Y</searchLink>; Department of Respiratory Medicine & Clinical Allergy, Fujita Health University, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuchi+H%22">Kikuchi H</searchLink>; 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