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Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.

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Title: Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.
Authors: Antoniou T; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada., Yang J; ICES, Toronto, Ontario, Canada., Juurlink DN; ICES, Toronto, Ontario, Canada.; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Ho JM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Schlegel Research Institute for Aging, Waterloo, Ontario, Canada.; GeriMedRisk, Waterloo, Ontario, Canada., Mamdani M; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana Faculty of Public Health, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada., Wu F; ICES, Toronto, Ontario, Canada., Tadrous M; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Women's College Research Institute, Toronto, Ontario, Canada., Gomes T; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada.; Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2026 Jul; Vol. 120 (1), pp. 122-138. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.
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  Data: <searchLink fieldCode="AU" term="%22Antoniou+T%22">Antoniou T</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Juurlink+DN%22">Juurlink DN</searchLink>; ICES, Toronto, Ontario, Canada.; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ho+JM%22">Ho JM</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Schlegel Research Institute for Aging, Waterloo, Ontario, Canada.; GeriMedRisk, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mamdani+M%22">Mamdani M</searchLink>; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana Faculty of Public Health, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tadrous+M%22">Tadrous M</searchLink>; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Women's College Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gomes+T%22">Gomes T</searchLink>; ICES, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada.; Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1002/cpt.70267
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      – Code: eng
        Text: English
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        StartPage: 122
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      – TitleFull: Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.
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            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
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