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Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.

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Title: Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.
Authors: Oyabu M; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan., Sakaue M; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan., Kubo A; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan., Yoshioka K; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.; Institute for Research on Productive Aging, Tokyo 108-0075, Japan., Kawaguchi R; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan., Yamamoto H; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan., Kinjo Y; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan., Kwon J; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan., Nishi H; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.; Department of Science and Engineering, Saitama University, Saitama City, Saitama 338-8570, Japan., Yamanaka D; Department of Veterinary Medical Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan., Sato T; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan., Mori D; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan., Eguchi T; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan., Ito N; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan., Fukada SI; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan., Suganami T; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan., Miura S; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan., Ono Y; Department of Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.; Muscle Biology Laboratory, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo 173-0015, Japan., Hakuno F; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan., Takahashi SI; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan., Goto T; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan., Kamei Y; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2600036123. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.
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  Data: <searchLink fieldCode="AU" term="%22Oyabu+M%22">Oyabu M</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Sakaue+M%22">Sakaue M</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Kubo+A%22">Kubo A</searchLink>; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshioka+K%22">Yoshioka K</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.; Institute for Research on Productive Aging, Tokyo 108-0075, Japan.<br /><searchLink fieldCode="AU" term="%22Kawaguchi+R%22">Kawaguchi R</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+H%22">Yamamoto H</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Kinjo+Y%22">Kinjo Y</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Kwon+J%22">Kwon J</searchLink>; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.<br /><searchLink fieldCode="AU" term="%22Nishi+H%22">Nishi H</searchLink>; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.; Department of Science and Engineering, Saitama University, Saitama City, Saitama 338-8570, Japan.<br /><searchLink fieldCode="AU" term="%22Yamanaka+D%22">Yamanaka D</searchLink>; Department of Veterinary Medical Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+D%22">Mori D</searchLink>; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+T%22">Eguchi T</searchLink>; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+N%22">Ito N</searchLink>; Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Fukada+SI%22">Fukada SI</searchLink>; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Suganami+T%22">Suganami T</searchLink>; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.<br /><searchLink fieldCode="AU" term="%22Miura+S%22">Miura S</searchLink>; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.<br /><searchLink fieldCode="AU" term="%22Ono+Y%22">Ono Y</searchLink>; Department of Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.; Muscle Biology Laboratory, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo 173-0015, Japan.<br /><searchLink fieldCode="AU" term="%22Hakuno+F%22">Hakuno F</searchLink>; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+SI%22">Takahashi SI</searchLink>; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+T%22">Goto T</searchLink>; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.<br /><searchLink fieldCode="AU" term="%22Kamei+Y%22">Kamei Y</searchLink>; Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2600036123. <i>Date of Electronic Publication: </i>2026 Apr 08.
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