Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors.
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| Title: | Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors. |
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| Authors: | Cheng Y; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Li T; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China.; Shigatse Branch, Xinqiao Hospital, Army Medical University, Chongqing 857000, Tibet Autonomous Region, China., Wang M; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Lan C; Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China., Fan H; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China.; School of Medicine, Chongqing University, Chongqing 400030, China., He Z; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Liu Q; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Li F; Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China., Wang L; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Wang W; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Chen G; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Chen T; Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China., Mao M; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Ruan Q; Department of Blood Transfusion, Southwest Hospital, Army Medical University, Chongqing 400038, China., Wang L; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Zhang X; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Qi H; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Zhang Y; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Zhou X; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Duan J; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Luo C; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Wang C; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Ye S; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Kong W; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Guo H; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Niu Q; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Qin Z; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Yan Q; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Ma Q; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Zhang X; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China., Hu R; Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China., Feng H; Department of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Army Medical University, Chongqing 400038, China., Ping YF; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China.; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Bian XW; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China.; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China., Shi Y; Institute of Pathology & Southwest Cancer Center, First Affiliated Hospital (Southwest Hospital) and School of Basic Medical Sciences, Army Medical University (Third Military Medical University), and the Key Laboratory of Tumor Immunopathology, Ministry of Education (Third Military Medical University), Chongqing 400038, China.; Chongqing Yuyue Scientific Research Center for Pathology, Chongqing Institute of Advanced Pathology, Jinfeng Laboratory, Chongqing 400039, China. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Apr 08; Vol. 18 (844), pp. eaed1155. Date of Electronic Publication: 2026 Apr 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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