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Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease.

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Title: Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease.
Authors: Llibre-Guerra JJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Lu R; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine, St. Louis, MO., Clarens MF; Department of Cognitive Neurology, Instituto Neurológico Fleni, Buenos Aires, Argentina., Liu I; Department of Biostatistics, Brown University School of Public Health, Providence, RI., Renton A; Ronald M. Loeb Center for Alzheimer's Disease, Dept of Genetics and Genomic Sciences, Nash Family Dept of Neuroscience, Icahn School of Medicine at Mount Sinai, New York., Ryan NS; Department of Neurodegenerative Disease and UK Dementia Research Institute at Queen Square Institute of Neurology, University College London, United Kingdom., Goate AM; Ronald M. Loeb Center for Alzheimer's Disease, Dept of Genetics and Genomic Sciences, Nash Family Dept of Neuroscience, Icahn School of Medicine at Mount Sinai, New York., Aguillón D; Group of Neuroscience of Antioquia, GNA, Medical School, University of Antioquia, Medellin, Colombia., Allegri RF; Department of Cognitive Neurology, Instituto Neurológico Fleni, Buenos Aires, Argentina., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO., Berman S; Department of Neurology and Clinical and Translational Science, University of Pittsburgh, PA., Chhatwal JP; Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston., Chrem Mendez P; Department of Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina., Vigo G; Department of Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Day GS; Department of Neurology, Mayo Clinic in Florida, Jacksonville., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis., Fox NC; Department of Neurodegenerative Disease and UK Dementia Research Institute at Queen Square Institute of Neurology, University College London, United Kingdom., Gordon BA; Department of Radiology, Washington University School of Medicine, St. Louis, MO., Hassenstab J; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Huey ED; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Ikeuchi T; Brain Research Institute, Niigata University, Japan., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany., Lee JH; Asian Medical Center, Seoul, South Korea., Levey AI; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA., Levin J; Department of Neurology, LMU University Hospital, LMU Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Niimi Y; Unit for Early and Exploratory Clinical Development, University of Tokyo Hospital, Japan., Perrin RJ; Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO., Rosa-Neto P; McGill University Research Centre for Studies in Aging, Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada., Sánchez-Valle R; Alzheimer's and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, FRCB-IDIBAPS, University of Barcelona, Spain., Schofield PR; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, Australia; and.; School of Biomedical Sciences, Faculty of Health and Medicine, University of New South Wales, Sydney, Australia., Wang G; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Li Y; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Xiong C; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine, St. Louis, MO., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Karch C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Daniels AJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO., McDade E; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO.
Source: Neurology [Neurology] 2026 Apr 28; Vol. 106 (8), pp. e214804. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease.
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Loeb Center for Alzheimer's Disease, Dept of Genetics and Genomic Sciences, Nash Family Dept of Neuroscience, Icahn School of Medicine at Mount Sinai, New York.<br /><searchLink fieldCode="AU" term="%22Ryan+NS%22">Ryan NS</searchLink>; Department of Neurodegenerative Disease and UK Dementia Research Institute at Queen Square Institute of Neurology, University College London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Goate+AM%22">Goate AM</searchLink>; Ronald M. Loeb Center for Alzheimer's Disease, Dept of Genetics and Genomic Sciences, Nash Family Dept of Neuroscience, Icahn School of Medicine at Mount Sinai, New York.<br /><searchLink fieldCode="AU" term="%22Aguillón+D%22">Aguillón D</searchLink>; Group of Neuroscience of Antioquia, GNA, Medical School, University of Antioquia, Medellin, Colombia.<br /><searchLink fieldCode="AU" term="%22Allegri+RF%22">Allegri RF</searchLink>; Department of Cognitive Neurology, Instituto Neurológico Fleni, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Berman+S%22">Berman S</searchLink>; Department of Neurology and Clinical and Translational Science, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Chhatwal+JP%22">Chhatwal JP</searchLink>; Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston.<br /><searchLink fieldCode="AU" term="%22Chrem+Mendez+P%22">Chrem Mendez P</searchLink>; Department of Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Vigo+G%22">Vigo G</searchLink>; Department of Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Day+GS%22">Day GS</searchLink>; Department of Neurology, Mayo Clinic in Florida, Jacksonville.<br /><searchLink fieldCode="AU" term="%22Farlow+MR%22">Farlow MR</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Fox+NC%22">Fox NC</searchLink>; Department of Neurodegenerative Disease and UK Dementia Research Institute at Queen Square Institute of Neurology, University College London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gordon+BA%22">Gordon BA</searchLink>; 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Asian Medical Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Levey+AI%22">Levey AI</searchLink>; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Levin+J%22">Levin J</searchLink>; Department of Neurology, LMU University Hospital, LMU Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Niimi+Y%22">Niimi Y</searchLink>; Unit for Early and Exploratory Clinical Development, University of Tokyo Hospital, Japan.<br /><searchLink fieldCode="AU" term="%22Perrin+RJ%22">Perrin RJ</searchLink>; Department of Pathology and Immunology, School of Medicine, Washington University, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; McGill University Research Centre for Studies in Aging, Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Sánchez-Valle+R%22">Sánchez-Valle R</searchLink>; Alzheimer's and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, FRCB-IDIBAPS, University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schofield+PR%22">Schofield PR</searchLink>; Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, Australia; and.; School of Biomedical Sciences, Faculty of Health and Medicine, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Xiong+C%22">Xiong C</searchLink>; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Karch+C%22">Karch C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Daniels+AJ%22">Daniels AJ</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22McDade+E%22">McDade E</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Bateman+RJ%22">Bateman RJ</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO.
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  Data: <searchLink fieldCode="JN" term="%220401060%22">Neurology</searchLink> [Neurology] 2026 Apr 28; Vol. 106 (8), pp. e214804. <i>Date of Electronic Publication: </i>2026 Apr 08.
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