Synthetic super-enhancers enable precision viral immunotherapy.
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| Title: | Synthetic super-enhancers enable precision viral immunotherapy. |
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| Authors: | Koeber U; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; IQVIA RDS, Frankfurt am Main, Germany., Matjusaitis M; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Plurify, Cambridge, UK., Alfazema N; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Furlong K; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Wang Z; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., White R; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Hamdan A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Edinburgh Pathology, Royal Infirmary Edinburgh, NHS Lothian, Edinburgh, UK., Dewari P; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Morisse G; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Navarette M; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK., Willis R; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Wang J; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Clark MP; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Jacinto de Sousa C; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Hong HI; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Sheraz S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Southgate B; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Trogenix, Edinburgh, UK., Cholewa-Waclaw J; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Gogolok S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Morrison GM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Cancino FG; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK.; Laboratory of Immune Regulation, NDM Centre for Immuno-Oncology, University of Oxford, Oxford, UK., Robertson F; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK., Williams A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Rosser SJ; School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Brennan PM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Sieger D; Cancer Research UK Scotland Centre, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Soufi A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Quezada SA; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London, UK., Pollard SM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. steven.pollard@ed.ac.uk.; Cancer Research UK Scotland Centre, Edinburgh, UK. steven.pollard@ed.ac.uk. |
| Source: | Nature [Nature] 2026 May; Vol. 653 (8113), pp. 232-241. Date of Electronic Publication: 2026 Apr 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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