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TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival.

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Title: TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival.
Authors: Fang Y; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Qiu T; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Luo H; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Wang Y; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Yang C; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Wang M; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Dai Q; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Zheng W; Department of Pediatric Dentistry, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Yin R; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Xiao X; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China., Li Q; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China. liqintong@scu.edu.cn.
Source: EMBO reports [EMBO Rep] 2026 May; Vol. 27 (10), pp. 2703-2730. Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival.
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  Data: <searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Qiu+T%22">Qiu T</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Luo+H%22">Luo H</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Dai+Q%22">Dai Q</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Department of Pediatric Dentistry, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Yin+R%22">Yin R</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Xiao+X%22">Xiao X</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, 610041, Sichuan, China. liqintong@scu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 May; Vol. 27 (10), pp. 2703-2730. <i>Date of Electronic Publication: </i>2026 Apr 09.
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        Value: 10.1038/s44319-026-00759-8
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              Text: 2026 May
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