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The role of AI-powered molecular profiling in the diagnosis and management of cancers of unknown primary: a case report and literature review.

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Title: The role of AI-powered molecular profiling in the diagnosis and management of cancers of unknown primary: a case report and literature review.
Authors: Esmail A; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States., Hassanain H; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States., Xiu J; Charles W. Duncan Jr. Department of Medicine, Caris Life Sciences, Phoenix, AZ, United States., Abdelrahim M; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States.; Faculty of Medicine, The University of Jordan, Amman, Jordan.
Source: Frontiers in oncology [Front Oncol] 2026 Mar 25; Vol. 16, pp. 1664264. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Esmail+A%22">Esmail A</searchLink>; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Hassanain+H%22">Hassanain H</searchLink>; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Xiu+J%22">Xiu J</searchLink>; Charles W. Duncan Jr. Department of Medicine, Caris Life Sciences, Phoenix, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Abdelrahim+M%22">Abdelrahim M</searchLink>; Section of Gastrointestinal Oncology, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX, United States.; Faculty of Medicine, The University of Jordan, Amman, Jordan.
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  Data: <searchLink fieldCode="JN" term="%22101568867%22">Frontiers in oncology</searchLink> [Front Oncol] 2026 Mar 25; Vol. 16, pp. 1664264. <i>Date of Electronic Publication: </i>2026 Mar 25 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101568867 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2234-943X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222234943X%22">2234943X </searchLink><i>NLM ISO Abbreviation: </i>Front Oncol <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3389/fonc.2026.1664264
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        Text: English
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              Text: 2026 Mar 25
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