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White Matter Damage in Multiple Sclerosis Disproportionately Targets Default Mode, Executive Control, and Salience Networks.

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Title: White Matter Damage in Multiple Sclerosis Disproportionately Targets Default Mode, Executive Control, and Salience Networks.
Authors: Figley TD; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada.; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada., Kornelsen J; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada.; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada., Uddin MN; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada., Wong K; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada.; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada., Pirzada S; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada., Carter S; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada., Helmick CA; Departments of Psychiatry, Medicine, Psychology & Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 2E2, Canada., O'Grady CB; Department of Anesthesia and Biomedical Translational Imaging Centre, Dalhousie University, Halifax, Nova Scotia B3H 3A7, Canada., Mazerolle EL; Departments of Psychology and Computer Science, St. Francis Xavier University, Antigonish, Nova Scotia B2G 2W5, Canada., Patel R; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada.; Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba R3E 3N4, Canada., Bernstein CN; Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3N4, Canada., Fisk JD; Departments of Psychiatry, Medicine, Psychology & Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 2E2, Canada.; Nova Scotia Health, Halifax, Nova Scotia B3H 2Y9, Canada., Marrie RA; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3N4, Canada.; Nova Scotia Health, Halifax, Nova Scotia B3H 2Y9, Canada.; Departments of Medicine and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada., Figley CR; Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada chase.figley@umanitoba.ca.; Division of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada.; PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada.; Manitoba Multiple Sclerosis Research Centre, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada.
Corporate Authors: Comorbidity and Cognition in Multiple Sclerosis (CCOMS) Study Group
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Jun 03; Vol. 46 (22). Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
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