SenSet defines cell-type specific senescence signatures in the aged human lung.
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| Title: | SenSet defines cell-type specific senescence signatures in the aged human lung. |
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| Authors: | Hasanaj E; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Beaulieu D; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wang C; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA., Hu Q; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rosas L; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Ohio State University, Columbus, OH, USA., Bueno M; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sembrat JC; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pineda RH; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Melo-Narvaez MC; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Cardenes N; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yanwu Z; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yingze Z; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lafyatis R; Division of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Morris A; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Mora A; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA., Rojas M; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA., Li D; Department of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, USA., Rahman I; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Pryhuber GS; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA., Lehmann M; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Institute for Lung Health (ILH), German Center for Lung Research (DZL), Giessen, Germany., Alder J; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Gurkar A; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Finkel T; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ma Q; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA., Lugo-Martinez J; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Póczos B; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Bar-Joseph Z; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu.; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu., Eickelberg O; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. oliver.eickelberg@pitt.edu., Königshoff M; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. koenigm@pitt.edu. |
| Source: | The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3589-3638. Date of Electronic Publication: 2026 Apr 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41963555 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: SenSet defines cell-type specific senescence signatures in the aged human lung. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hasanaj+E%22">Hasanaj E</searchLink>; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Beaulieu+D%22">Beaulieu D</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Q%22">Hu Q</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+L%22">Rosas L</searchLink>; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bueno+M%22">Bueno M</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sembrat+JC%22">Sembrat JC</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pineda+RH%22">Pineda RH</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Melo-Narvaez+MC%22">Melo-Narvaez MC</searchLink>; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cardenes+N%22">Cardenes N</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yanwu+Z%22">Yanwu Z</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yingze+Z%22">Yingze Z</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lafyatis+R%22">Lafyatis R</searchLink>; Division of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+A%22">Morris A</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mora+A%22">Mora A</searchLink>; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rojas+M%22">Rojas M</searchLink>; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+I%22">Rahman I</searchLink>; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pryhuber+GS%22">Pryhuber GS</searchLink>; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lehmann+M%22">Lehmann M</searchLink>; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Institute for Lung Health (ILH), German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Alder+J%22">Alder J</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gurkar+A%22">Gurkar A</searchLink>; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Finkel+T%22">Finkel T</searchLink>; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Q%22">Ma Q</searchLink>; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lugo-Martinez+J%22">Lugo-Martinez J</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Póczos+B%22">Póczos B</searchLink>; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Joseph+Z%22">Bar-Joseph Z</searchLink>; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu.; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu.<br /><searchLink fieldCode="AU" term="%22Eickelberg+O%22">Eickelberg O</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. oliver.eickelberg@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Königshoff+M%22">Königshoff M</searchLink>; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. koenigm@pitt.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 May; Vol. 45 (10), pp. 3589-3638. <i>Date of Electronic Publication: </i>2026 Apr 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8208664 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2075 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202614189%22">02614189 </searchLink><i>NLM ISO Abbreviation: </i>EMBO J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41963555 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s44318-026-00762-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3589 Titles: – TitleFull: SenSet defines cell-type specific senescence signatures in the aged human lung. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hasanaj E – PersonEntity: Name: NameFull: Beaulieu D – PersonEntity: Name: NameFull: Wang C – PersonEntity: Name: NameFull: Hu Q – PersonEntity: Name: NameFull: Rosas L – PersonEntity: Name: NameFull: Bueno M – PersonEntity: Name: NameFull: Sembrat JC – PersonEntity: Name: NameFull: Pineda RH – PersonEntity: Name: NameFull: Melo-Narvaez MC – PersonEntity: Name: NameFull: Cardenes N – PersonEntity: Name: NameFull: Yanwu Z – PersonEntity: Name: NameFull: Yingze Z – PersonEntity: Name: NameFull: Lafyatis R – PersonEntity: Name: NameFull: Morris A – PersonEntity: Name: NameFull: Mora A – PersonEntity: Name: NameFull: Rojas M – PersonEntity: Name: NameFull: Li D – PersonEntity: Name: NameFull: Rahman I – PersonEntity: Name: NameFull: Pryhuber GS – PersonEntity: Name: NameFull: Lehmann M – PersonEntity: Name: NameFull: Alder J – PersonEntity: Name: NameFull: Gurkar A – PersonEntity: Name: NameFull: Finkel T – PersonEntity: Name: NameFull: Ma Q – PersonEntity: Name: NameFull: Lugo-Martinez J – PersonEntity: Name: NameFull: Póczos B – PersonEntity: Name: NameFull: Bar-Joseph Z – PersonEntity: Name: NameFull: Eickelberg O – PersonEntity: Name: NameFull: Königshoff M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1460-2075 Numbering: – Type: volume Value: 45 – Type: issue Value: 10 Titles: – TitleFull: The EMBO journal Type: main |
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