SenSet defines cell-type specific senescence signatures in the aged human lung.
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| Title: | SenSet defines cell-type specific senescence signatures in the aged human lung. |
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| Authors: | Hasanaj E; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Beaulieu D; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wang C; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA., Hu Q; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rosas L; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Ohio State University, Columbus, OH, USA., Bueno M; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sembrat JC; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pineda RH; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Melo-Narvaez MC; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Cardenes N; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yanwu Z; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yingze Z; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lafyatis R; Division of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Morris A; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Mora A; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA., Rojas M; Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH, USA., Li D; Department of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, USA., Rahman I; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Pryhuber GS; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA., Lehmann M; Comprehensive Pneumology Center (CPC) with the CPC-M bioArchive / Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum München; Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Institute for Lung Health (ILH), German Center for Lung Research (DZL), Giessen, Germany., Alder J; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Gurkar A; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Finkel T; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ma Q; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA., Lugo-Martinez J; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Póczos B; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Bar-Joseph Z; Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu.; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. zivbj@cs.cmu.edu., Eickelberg O; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. oliver.eickelberg@pitt.edu., Königshoff M; Center of Lung Aging and Regeneration, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. koenigm@pitt.edu. |
| Source: | The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3589-3638. Date of Electronic Publication: 2026 Apr 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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