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iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

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Title: iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.
Authors: Diotallevi M; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. marina.diotallevi@cardiov.ox.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. marina.diotallevi@cardiov.ox.ac.uk., Outeiral C; Oxford Protein Informatics Group, University of Oxford, Oxford, UK., Patel P; Department of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Purvis GSD; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK., Chuaiphichai S; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK., Nicol T; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK., Ayaz F; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK., Nissley DA; Oxford Protein Informatics Group, University of Oxford, Oxford, UK., Krasnoselska GO; Structural Biology, Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.; Protein Production UK, The Research Complex at Harwell, Science Campus, Didcot, UK., Hester S; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McVey JH; Department of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Fischer R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kessler B; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Deane CM; Oxford Protein Informatics Group, University of Oxford, Oxford, UK., Owens RJ; Structural Biology, Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.; Protein Production UK, The Research Complex at Harwell, Science Campus, Didcot, UK.; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, UK., Channon KM; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. keith.channon@cardiov.ox.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. keith.channon@cardiov.ox.ac.uk., Crabtree MJ; BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. mark.crabtree@surrey.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. mark.crabtree@surrey.ac.uk.; Department of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK. mark.crabtree@surrey.ac.uk.
Source: Nature metabolism [Nat Metab] 2026 Apr; Vol. 8 (4), pp. 855-868. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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