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Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence.

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Title: Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence.
Authors: Sopena-Rios M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Ripoll-Cladellas A; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Omidi F; Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain., Ballouz S; School of Computer Science and Engineering, University of New South Wales, Sydney, New South Wales, Australia., Alquicira-Hernandez J; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Divisions of Rheumatology and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Translational Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia., Oelen R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Department of Ophthalmology, Royal Hobart Hospital, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Powell JE; Translational Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Melé M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain. marta.mele@bsc.es.
Source: Nature aging [Nat Aging] 2026 Apr; Vol. 6 (4), pp. 932-949. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sopena-Rios+M%22">Sopena-Rios M</searchLink>; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ripoll-Cladellas+A%22">Ripoll-Cladellas A</searchLink>; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Omidi+F%22">Omidi F</searchLink>; Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ballouz+S%22">Ballouz S</searchLink>; School of Computer Science and Engineering, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Alquicira-Hernandez+J%22">Alquicira-Hernandez J</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Divisions of Rheumatology and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Translational Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Oelen+R%22">Oelen R</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hewitt+AW%22">Hewitt AW</searchLink>; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Department of Ophthalmology, Royal Hobart Hospital, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Franke+L%22">Franke L</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Wijst+MGP%22">van der Wijst MGP</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Powell+JE%22">Powell JE</searchLink>; Translational Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Melé+M%22">Melé M</searchLink>; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain. marta.mele@bsc.es.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Apr; Vol. 6 (4), pp. 932-949. <i>Date of Electronic Publication: </i>2026 Apr 10.
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