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Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.

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Title: Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.
Authors: Filippi K; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany., Graf-Riesen K; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany., Kuppusamy M; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Department Metabolism, Senescence and Autophagy, Research Center One Health Ruhr, University Alliance Ruhr & University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany., Unger A; Institute of Physiology II, University of Muenster, Muenster, Germany., Kimura K; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, 305-8577, Japan., Matijass M; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany., Baeta H; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Institute of Biology II, University of Freiburg, 79104, Freiburg, Germany., Podlacha M; Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland., Haertter D; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany., Kudin AP; Institute of Experimental Epileptology and Neurocognition, University Bonn Medical Center, 53105, Bonn, Germany.; Department of Epileptology, University Bonn Medical Center, 53105, Bonn, Germany., Wiemann M; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany., Węgrzyn G; Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland., Kornblum C; Department of Neurology, University Bonn Medical Center, 53105, Bonn, Germany., Reimann J; Department of Neurology, University Bonn Medical Center, 53105, Bonn, Germany., Linke WA; Institute of Physiology II, University of Muenster, Muenster, Germany., Huesgen PF; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Institute of Biology II, University of Freiburg, 79104, Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signaling Studies, University of Freiburg, 79104, Freiburg, Germany., Kunz WS; Institute of Experimental Epileptology and Neurocognition, University Bonn Medical Center, 53105, Bonn, Germany.; Department of Epileptology, University Bonn Medical Center, 53105, Bonn, Germany., Fleischmann BK; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany., Hesse M; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany. mhesse1@uni-bonn.de.
Source: Nature communications [Nat Commun] 2026 Apr 11; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.
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  Data: <searchLink fieldCode="AU" term="%22Filippi+K%22">Filippi K</searchLink>; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Graf-Riesen+K%22">Graf-Riesen K</searchLink>; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kuppusamy+M%22">Kuppusamy M</searchLink>; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Department Metabolism, Senescence and Autophagy, Research Center One Health Ruhr, University Alliance Ruhr & University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Unger+A%22">Unger A</searchLink>; Institute of Physiology II, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Kimura+K%22">Kimura K</searchLink>; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, 305-8577, Japan.<br /><searchLink fieldCode="AU" term="%22Matijass+M%22">Matijass M</searchLink>; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Baeta+H%22">Baeta H</searchLink>; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Institute of Biology II, University of Freiburg, 79104, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Podlacha+M%22">Podlacha M</searchLink>; Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.<br /><searchLink fieldCode="AU" term="%22Haertter+D%22">Haertter D</searchLink>; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kudin+AP%22">Kudin AP</searchLink>; Institute of Experimental Epileptology and Neurocognition, University Bonn Medical Center, 53105, Bonn, Germany.; Department of Epileptology, University Bonn Medical Center, 53105, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wiemann+M%22">Wiemann M</searchLink>; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Węgrzyn+G%22">Węgrzyn G</searchLink>; Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.<br /><searchLink fieldCode="AU" term="%22Kornblum+C%22">Kornblum C</searchLink>; Department of Neurology, University Bonn Medical Center, 53105, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Reimann+J%22">Reimann J</searchLink>; Department of Neurology, University Bonn Medical Center, 53105, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Linke+WA%22">Linke WA</searchLink>; Institute of Physiology II, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Huesgen+PF%22">Huesgen PF</searchLink>; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.; Institute of Biology II, University of Freiburg, 79104, Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signaling Studies, University of Freiburg, 79104, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kunz+WS%22">Kunz WS</searchLink>; Institute of Experimental Epileptology and Neurocognition, University Bonn Medical Center, 53105, Bonn, Germany.; Department of Epileptology, University Bonn Medical Center, 53105, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischmann+BK%22">Fleischmann BK</searchLink>; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hesse+M%22">Hesse M</searchLink>; Institute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany. mhesse1@uni-bonn.de.
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