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Phase 2 study of cabozantinib (XL184) with nivolumab and ipilimumab for the treatment of poorly differentiated neuroendocrine carcinomas (ETCTN10315).

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Title: Phase 2 study of cabozantinib (XL184) with nivolumab and ipilimumab for the treatment of poorly differentiated neuroendocrine carcinomas (ETCTN10315).
Authors: Mandl A; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Chen R; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Das S; Vanderbilt University Medical Center, Nashville, TN, USA., Strosberg JR; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Kasi A; University of Kansas Cancer Center, Kansas City, KS, USA., Konda B; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Li D; City of Hope National Medical Center, Duarte, CA, USA., Burns TF; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Chauhan A; Sylvester Comprehensive Cancer Center, University of Miami, FL, USA., Ciombor KK; Vanderbilt University Medical Center, Nashville, TN, USA., Dayyani F; Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA, USA., Dorff T; City of Hope National Medical Center, Duarte, CA, USA., Ohr JP; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Patel BB; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Sukrithan V; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, Columbus, OH, USA., Soares HP; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Chen K; Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Obstetrics and Gynecology, Detroit, MI, USA., Liu SV; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Tesfaye AA; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Carducci MA; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Beumer JH; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Source: The oncologist [Oncologist] 2026 May 08; Vol. 31 (6).
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase 2 study of cabozantinib (XL184) with nivolumab and ipilimumab for the treatment of poorly differentiated neuroendocrine carcinomas (ETCTN10315).
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  Data: <searchLink fieldCode="AU" term="%22Mandl+A%22">Mandl A</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Strosberg+JR%22">Strosberg JR</searchLink>; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kasi+A%22">Kasi A</searchLink>; University of Kansas Cancer Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Konda+B%22">Konda B</searchLink>; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burns+TF%22">Burns TF</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chauhan+A%22">Chauhan A</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ciombor+KK%22">Ciombor KK</searchLink>; Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Dayyani+F%22">Dayyani F</searchLink>; Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dorff+T%22">Dorff T</searchLink>; City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ohr+JP%22">Ohr JP</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+BB%22">Patel BB</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Sukrithan+V%22">Sukrithan V</searchLink>; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Soares+HP%22">Soares HP</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Obstetrics and Gynecology, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+SV%22">Liu SV</searchLink>; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Tesfaye+AA%22">Tesfaye AA</searchLink>; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Carducci+MA%22">Carducci MA</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Beumer+JH%22">Beumer JH</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
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  Data: <searchLink fieldCode="JN" term="%229607837%22">The oncologist</searchLink> [Oncologist] 2026 May 08; Vol. 31 (6).
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      – TitleFull: Phase 2 study of cabozantinib (XL184) with nivolumab and ipilimumab for the treatment of poorly differentiated neuroendocrine carcinomas (ETCTN10315).
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              Text: 2026 May 08
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