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Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults.

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Title: Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults.
Authors: Silman D; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Flaxman A; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Datoo M; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Edwards NJ; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Ramos-Lopez F; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Mitton C; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Mair C; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Bellamy D; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Bowyer G; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Morter R; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Halbroth B; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Venkatraman N; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Folegatti PM; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Marshall J; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Poulton I; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Bajer A; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Salman AM; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Berrie E; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, England, OX3 7JT, UK., Baum J; Department of Life Sciences, Imperial College London Faculty of Natural Sciences, London, England, SW7 2AZ, UK.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, 2052, Australia., Blagborough AM; Department of Life Sciences, Imperial College London Faculty of Natural Sciences, London, England, SW7 2AZ, UK.; University of Cambridge Department of Pathology, Cambridge, England, CB1 2QP, UK., Crocker W; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Roberts R; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Lawrie AM; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK., Spencer AJ; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; School of Biomedical Science and Pharmacy, The University of Newcastle College of Health Medicine and Wellbeing, Callaghan, New South Wales, 2308, Australia., Gilbert SC; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK., Ewer KJ; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Global Health Vaccines R&D, GSK Vaccines Institute for Global Health, Siena, Italy., Hill AVS; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.
Source: Wellcome open research [Wellcome Open Res] 2026 Apr 06; Vol. 9, pp. 734. Date of Electronic Publication: 2026 Apr 06 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Wellcome Trust Country of Publication: England NLM ID: 101696457 Publication Model: eCollection Cited Medium: Print ISSN: 2398-502X (Print) Linking ISSN: 2398502X NLM ISO Abbreviation: Wellcome Open Res Subsets: PubMed not MEDLINE
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  Data: Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults.
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  Data: <searchLink fieldCode="AU" term="%22Silman+D%22">Silman D</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Flaxman+A%22">Flaxman A</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Datoo+M%22">Datoo M</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+NJ%22">Edwards NJ</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Ramos-Lopez+F%22">Ramos-Lopez F</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Mitton+C%22">Mitton C</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Mair+C%22">Mair C</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Bowyer+G%22">Bowyer G</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Morter+R%22">Morter R</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Halbroth+B%22">Halbroth B</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Venkatraman+N%22">Venkatraman N</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Folegatti+PM%22">Folegatti PM</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+J%22">Marshall J</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Poulton+I%22">Poulton I</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Bajer+A%22">Bajer A</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Salman+AM%22">Salman AM</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Berrie+E%22">Berrie E</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, England, OX3 7JT, UK.<br /><searchLink fieldCode="AU" term="%22Baum+J%22">Baum J</searchLink>; Department of Life Sciences, Imperial College London Faculty of Natural Sciences, London, England, SW7 2AZ, UK.; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Blagborough+AM%22">Blagborough AM</searchLink>; Department of Life Sciences, Imperial College London Faculty of Natural Sciences, London, England, SW7 2AZ, UK.; University of Cambridge Department of Pathology, Cambridge, England, CB1 2QP, UK.<br /><searchLink fieldCode="AU" term="%22Crocker+W%22">Crocker W</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+AM%22">Lawrie AM</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, England, OX3 7LJ, UK.<br /><searchLink fieldCode="AU" term="%22Spencer+AJ%22">Spencer AJ</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; School of Biomedical Science and Pharmacy, The University of Newcastle College of Health Medicine and Wellbeing, Callaghan, New South Wales, 2308, Australia.<br /><searchLink fieldCode="AU" term="%22Gilbert+SC%22">Gilbert SC</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.; Global Health Vaccines R&D, GSK Vaccines Institute for Global Health, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Jenner Institute, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford Nuffield Department of Medicine, Oxford, England, OX3 7DQ, UK.
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