Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis.

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Title: Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis.
Authors: Hanff AM; Faculty of Sciences Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Epidemiology, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Centre+, Maastricht, Netherlands.; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands., McCrum C; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands., Rauschenberger A; Bioinformatics & AI, Department of Medical Informatics, Luxembourg Institute of Health, Strassen, Luxembourg., Pachchek S; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Aguayo GA; Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg., Pauly C; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg., Jónsdóttir SR; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg., Tsurkalenko O; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.; Digital Medicine Group, Luxembourg Institute of Health, Strassen, Luxembourg., Pauly L; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg., Landoulsi Z; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Leist AK; Department of Social Sciences, University of Luxembourg, Esch-sur-Alzette, Luxembourg., May P; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Zeegers MP; Department of Epidemiology, Care and Public Health Research Institute, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands., Krüger R; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Source: Frontiers in aging neuroscience [Front Aging Neurosci] 2026 Mar 26; Vol. 18, pp. 1771789. Date of Electronic Publication: 2026 Mar 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hanff+AM%22">Hanff AM</searchLink>; Faculty of Sciences Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Epidemiology, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Centre+, Maastricht, Netherlands.; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22McCrum+C%22">McCrum C</searchLink>; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rauschenberger+A%22">Rauschenberger A</searchLink>; Bioinformatics & AI, Department of Medical Informatics, Luxembourg Institute of Health, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Pachchek+S%22">Pachchek S</searchLink>; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Aguayo+GA%22">Aguayo GA</searchLink>; Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Pauly+C%22">Pauly C</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Jónsdóttir+SR%22">Jónsdóttir SR</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Tsurkalenko+O%22">Tsurkalenko O</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.; Digital Medicine Group, Luxembourg Institute of Health, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Pauly+L%22">Pauly L</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Landoulsi+Z%22">Landoulsi Z</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Leist+AK%22">Leist AK</searchLink>; Department of Social Sciences, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22May+P%22">May P</searchLink>; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Zeegers+MP%22">Zeegers MP</searchLink>; Department of Epidemiology, Care and Public Health Research Institute, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Krüger+R%22">Krüger R</searchLink>; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Translational Neurosciences, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
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