Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway.

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Title: Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway.
Authors: Liao R; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Luo J; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China., Li X; Department of Pharmacy, The Second People's Hospital of Yibin, Yibin, China., Tang X; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Huang M; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhou L; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Yun L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Z; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Jiang P; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Wang X; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China., Gan X; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Wang L; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China., Wu J; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.; Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 27; Vol. 17, pp. 1730028. Date of Electronic Publication: 2026 Mar 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway.
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  Data: <searchLink fieldCode="AU" term="%22Liao+R%22">Liao R</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Pharmacy, The Second People's Hospital of Yibin, Yibin, China.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Yun+L%22">Yun L</searchLink>; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+P%22">Jiang P</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Gan+X%22">Gan X</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.; Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Mar 27; Vol. 17, pp. 1730028. <i>Date of Electronic Publication: </i>2026 Mar 27 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1730028
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              Text: 2026 Mar 27
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