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Phase I studies assessing safety and pharmacokinetics of nacubactam administered alone or in combination with cefepime or aztreonam in Japanese healthy participants.

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Title: Phase I studies assessing safety and pharmacokinetics of nacubactam administered alone or in combination with cefepime or aztreonam in Japanese healthy participants.
Authors: Morita J; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan., Hida N; Department of Clinical Research and Development, Graduate School of Pharmacy, Showa Medical University, Setagaya-ku, Tokyo, Japan.; SHOWA Medical University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Setagaya-ku, Tokyo, Japan., Yonemura T; Souseikai Sumida Hospital, Tokyo, Japan., Yamazaki T; Department of Clinical Research and Development, Graduate School of Pharmacy, Showa Medical University, Setagaya-ku, Tokyo, Japan.; SHOWA Medical University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Setagaya-ku, Tokyo, Japan., Sato H; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan., Sumiya M; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan., Takaya R; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan., Kumagai Y; Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, Japan., Uchida N; Department of Clinical Pharmacology, Graduate School of Medicine, SHOWA Medical University, Setagaya-ku, Tokyo, Japan.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 May 06; Vol. 70 (5), pp. e0177025. Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I studies assessing safety and pharmacokinetics of nacubactam administered alone or in combination with cefepime or aztreonam in Japanese healthy participants.
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  Data: <searchLink fieldCode="AU" term="%22Morita+J%22">Morita J</searchLink>; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hida+N%22">Hida N</searchLink>; Department of Clinical Research and Development, Graduate School of Pharmacy, Showa Medical University, Setagaya-ku, Tokyo, Japan.; SHOWA Medical University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Setagaya-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yonemura+T%22">Yonemura T</searchLink>; Souseikai Sumida Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamazaki+T%22">Yamazaki T</searchLink>; Department of Clinical Research and Development, Graduate School of Pharmacy, Showa Medical University, Setagaya-ku, Tokyo, Japan.; SHOWA Medical University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Setagaya-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+H%22">Sato H</searchLink>; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sumiya+M%22">Sumiya M</searchLink>; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takaya+R%22">Takaya R</searchLink>; R & D Division, Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kumagai+Y%22">Kumagai Y</searchLink>; Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Uchida+N%22">Uchida N</searchLink>; Department of Clinical Pharmacology, Graduate School of Medicine, SHOWA Medical University, Setagaya-ku, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 May 06; Vol. 70 (5), pp. e0177025. <i>Date of Electronic Publication: </i>2026 Apr 13.
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  Data: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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        Value: 10.1128/aac.01770-25
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        Text: English
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              Text: 2026 May 06
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