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Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the AppNL-G-F Mouse Model of Alzheimer's Disease.

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Title: Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the AppNL-G-F Mouse Model of Alzheimer's Disease.
Authors: Sweeney EM; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Abate G; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Bakker BRV; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden., Mastinu A; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Lai Y; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.; Department of Biological Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Uberti D; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Nilsson P; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden., Tambaro S; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Source: Aging cell [Aging Cell] 2026 Apr; Vol. 25 (4), pp. e70478.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the App<superscript>NL-G-F</superscript> Mouse Model of Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Sweeney+EM%22">Sweeney EM</searchLink>; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Abate+G%22">Abate G</searchLink>; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bakker+BRV%22">Bakker BRV</searchLink>; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Mastinu+A%22">Mastinu A</searchLink>; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.; Department of Biological Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy.<br /><searchLink fieldCode="AU" term="%22Uberti+D%22">Uberti D</searchLink>; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Nilsson+P%22">Nilsson P</searchLink>; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Tambaro+S%22">Tambaro S</searchLink>; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22101130839%22">Aging cell</searchLink> [Aging Cell] 2026 Apr; Vol. 25 (4), pp. e70478.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101130839 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-9726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214749718%22">14749718 </searchLink><i>NLM ISO Abbreviation: </i>Aging Cell <i>Subsets: </i>MEDLINE
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      – TitleFull: Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the AppNL-G-F Mouse Model of Alzheimer's Disease.
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              Text: 2026 Apr
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