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Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.

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Title: Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.
Authors: Perry RN; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville., Lenert G; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville., Benavente ED; Laboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands., Bölük A; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.)., Hernandez R; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles., Ma L; Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (L. Ma)., Barbera N; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville., Watts K; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville., Mendoza VD; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles., Örd T; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.)., Taipale M; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.)., Sachs N; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel)., Pauli J; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel)., Mokry M; Central Diagnostic Laboratory (M. Mokry), University Medical Center Utrecht, Utrecht University, the Netherlands., de Kleijn DPV; Department of Vascular Surgery (D.P.V.d.K.), University Medical Center Utrecht, Utrecht University, the Netherlands., de Winther MPJ; Department of Medical Biochemistry, Experimental Vascular Biology, Atherosclerosis and Ischemic Syndromes, Amsterdam Cardiovascular Sciences, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, the Netherlands (M.P.J.d.W.)., Mayr M; National Heart and Lung Institute, Imperial College London, United Kingdom (M. Mayr).; Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (M. Mayr)., Maegdefessel L; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden (L. Maegdefessel).; German Center for Cardiovascular Research (DZHK), Berlin (L. Maegdefessel)., Reue K; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.; David Geffen School of Medicine, and Molecular Biology Institute (K.R., M.C.), University of California, Los Angeles., Kaikkonen MU; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.)., Björkegren JLM; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden (J.L.M.B.).; Clinical Gene Networks AB, Stockholm, Sweden (J.L.M.B.)., den Ruijter HM; Laboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands., Civelek M; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.; Department of Anesthesiology and Perioperative Medicine (M.C.), University of California, Los Angeles.; Institute for Precision Health (M.C.), University of California, Los Angeles.; David Geffen School of Medicine, and Molecular Biology Institute (K.R., M.C.), University of California, Los Angeles.
Source: Circulation research [Circ Res] 2026 May 08; Vol. 138 (10), pp. e326941. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.
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  Data: <searchLink fieldCode="AU" term="%22Perry+RN%22">Perry RN</searchLink>; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Lenert+G%22">Lenert G</searchLink>; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Benavente+ED%22">Benavente ED</searchLink>; Laboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bölük+A%22">Bölük A</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).<br /><searchLink fieldCode="AU" term="%22Hernandez+R%22">Hernandez R</searchLink>; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (L. Ma).<br /><searchLink fieldCode="AU" term="%22Barbera+N%22">Barbera N</searchLink>; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Watts+K%22">Watts K</searchLink>; Department of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.; Department of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Mendoza+VD%22">Mendoza VD</searchLink>; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Örd+T%22">Örd T</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).<br /><searchLink fieldCode="AU" term="%22Taipale+M%22">Taipale M</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).<br /><searchLink fieldCode="AU" term="%22Sachs+N%22">Sachs N</searchLink>; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).<br /><searchLink fieldCode="AU" term="%22Pauli+J%22">Pauli J</searchLink>; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).<br /><searchLink fieldCode="AU" term="%22Mokry+M%22">Mokry M</searchLink>; Central Diagnostic Laboratory (M. Mokry), University Medical Center Utrecht, Utrecht University, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Kleijn+DPV%22">de Kleijn DPV</searchLink>; Department of Vascular Surgery (D.P.V.d.K.), University Medical Center Utrecht, Utrecht University, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Winther+MPJ%22">de Winther MPJ</searchLink>; Department of Medical Biochemistry, Experimental Vascular Biology, Atherosclerosis and Ischemic Syndromes, Amsterdam Cardiovascular Sciences, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, the Netherlands (M.P.J.d.W.).<br /><searchLink fieldCode="AU" term="%22Mayr+M%22">Mayr M</searchLink>; National Heart and Lung Institute, Imperial College London, United Kingdom (M. Mayr).; Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (M. Mayr).<br /><searchLink fieldCode="AU" term="%22Maegdefessel+L%22">Maegdefessel L</searchLink>; Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden (L. Maegdefessel).; German Center for Cardiovascular Research (DZHK), Berlin (L. Maegdefessel).<br /><searchLink fieldCode="AU" term="%22Reue+K%22">Reue K</searchLink>; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.; David Geffen School of Medicine, and Molecular Biology Institute (K.R., M.C.), University of California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Kaikkonen+MU%22">Kaikkonen MU</searchLink>; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).<br /><searchLink fieldCode="AU" term="%22Björkegren+JLM%22">Björkegren JLM</searchLink>; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden (J.L.M.B.).; Clinical Gene Networks AB, Stockholm, Sweden (J.L.M.B.).<br /><searchLink fieldCode="AU" term="%22den+Ruijter+HM%22">den Ruijter HM</searchLink>; Laboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Civelek+M%22">Civelek M</searchLink>; Department of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.; Department of Anesthesiology and Perioperative Medicine (M.C.), University of California, Los Angeles.; Institute for Precision Health (M.C.), University of California, Los Angeles.; David Geffen School of Medicine, and Molecular Biology Institute (K.R., M.C.), University of California, Los Angeles.
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