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Hepatic Sirt2-PARP1-HMGB1 axis promotes exercise-mediated amelioration of MASH in mice.

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Title: Hepatic Sirt2-PARP1-HMGB1 axis promotes exercise-mediated amelioration of MASH in mice.
Authors: Li S; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Mu WJ; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Zhao ZA; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Peng WQ; Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Zhu JY; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Li RY; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Yan LJ; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Li Y; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Luo HY; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Chen M; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Yin MT; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Li X; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Chen HM; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Yang YL; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Liu Q; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Li L; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China., Guo L; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.
Source: Science China. Life sciences [Sci China Life Sci] 2026 Jul; Vol. 69 (7), pp. 2342-2359. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
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  Label: Title
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  Data: Hepatic Sirt2-PARP1-HMGB1 axis promotes exercise-mediated amelioration of MASH in mice.
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  Data: <searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Mu+WJ%22">Mu WJ</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhao+ZA%22">Zhao ZA</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Peng+WQ%22">Peng WQ</searchLink>; Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Zhu+JY%22">Zhu JY</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Li+RY%22">Li RY</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Yan+LJ%22">Yan LJ</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Luo+HY%22">Luo HY</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Yin+MT%22">Yin MT</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Chen+HM%22">Chen HM</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Yang+YL%22">Yang YL</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China. guoliang@sus.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101529880%22">Science China. Life sciences</searchLink> [Sci China Life Sci] 2026 Jul; Vol. 69 (7), pp. 2342-2359. <i>Date of Electronic Publication: </i>2026 Apr 10.
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