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The orphan receptor GPR84 drives inflammation in Buruli ulcer development.

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Title: The orphan receptor GPR84 drives inflammation in Buruli ulcer development.
Authors: Foulon M; Department of Biochemistry, Faculty of Sciences, University of Geneva, Science II, CH-1211 Geneva, Switzerland.; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France., G Fraga A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal., Robbe-Saule M; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France., Tarnaud F; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France., Lafont M; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France., Lebon G; Molecular and Structural Mechanisms of Neuromodulation, Institut de Génomique Fonctionnelle, UMR 5203 CNRS - U 1191 INSERM - University of Montpellier, F-34094 Montpellier, France., Fevereiro J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal., Pignon P; University of Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000 Angers, France., Boneca IG; Biology and Genetics of Bacterial Cell Wall Unit, Institut Pasteur, University Paris Cité, INSERM U1306, F-75015 Paris, France., Fanton D'Andon M; Biology and Genetics of Bacterial Cell Wall Unit, Institut Pasteur, University Paris Cité, INSERM U1306, F-75015 Paris, France., Martin L; Service de dermatologie, CHU Angers, F-49933 Angers, France., Croué A; Département de Pathologie, CHU Angers, F-49933 Angers, France., Gouault N; University of Rennes, CNRS, ISCR, UMR 6226, F-35700 Rennes, France., Sauvager A; University of Rennes, CNRS, ISCR, UMR 6226, F-35700 Rennes, France., Meunier E; Institute of Pharmacology and Structural Biology, University of Toulouse, CNRS, F-31400 Toulouse, France., Brodin P; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France., Touami L; NUMECAN, U-1317 Inserm - U-1341 Inrae - Université de Rennes 1, F-35000 Rennes, France., Labarrière N; INCIT, Inserm, University of Nantes, CHU Nantes, F-44200 Nantes, France., Ganlonon L; Centre de Diagnostic et de Traitement de l'Ulcère de Buruli et de la Lèpre de Pobè, Fondation Raoul Follereau, Pobè, BP 191, 99999 Bénin, France., Adeye A; Centre de Diagnostic et de Traitement de l'Ulcère de Buruli et de la Lèpre de Pobè, Fondation Raoul Follereau, Pobè, BP 191, 99999 Bénin, France., Marion E; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France., Dubee V; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.; Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire d'Angers, F-49933 Angers, France., Pedrosa J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal., Yeramian E; Unité de Microbiologie Structurale, Institut Pasteur, CNRS, University Paris Cité, F-75015 Paris, France., Marsollier L; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.
Source: Science translational medicine [Sci Transl Med] 2026 Apr 15; Vol. 18 (845), pp. eads8681. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Foulon+M%22">Foulon M</searchLink>; Department of Biochemistry, Faculty of Sciences, University of Geneva, Science II, CH-1211 Geneva, Switzerland.; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22G+Fraga+A%22">G Fraga A</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Robbe-Saule+M%22">Robbe-Saule M</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Tarnaud+F%22">Tarnaud F</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Lafont+M%22">Lafont M</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Lebon+G%22">Lebon G</searchLink>; Molecular and Structural Mechanisms of Neuromodulation, Institut de Génomique Fonctionnelle, UMR 5203 CNRS - U 1191 INSERM - University of Montpellier, F-34094 Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Fevereiro+J%22">Fevereiro J</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Pignon+P%22">Pignon P</searchLink>; University of Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Boneca+IG%22">Boneca IG</searchLink>; Biology and Genetics of Bacterial Cell Wall Unit, Institut Pasteur, University Paris Cité, INSERM U1306, F-75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Fanton+D'Andon+M%22">Fanton D'Andon M</searchLink>; Biology and Genetics of Bacterial Cell Wall Unit, Institut Pasteur, University Paris Cité, INSERM U1306, F-75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Martin+L%22">Martin L</searchLink>; Service de dermatologie, CHU Angers, F-49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Croué+A%22">Croué A</searchLink>; Département de Pathologie, CHU Angers, F-49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Gouault+N%22">Gouault N</searchLink>; University of Rennes, CNRS, ISCR, UMR 6226, F-35700 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Sauvager+A%22">Sauvager A</searchLink>; University of Rennes, CNRS, ISCR, UMR 6226, F-35700 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Meunier+E%22">Meunier E</searchLink>; Institute of Pharmacology and Structural Biology, University of Toulouse, CNRS, F-31400 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Brodin+P%22">Brodin P</searchLink>; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Touami+L%22">Touami L</searchLink>; NUMECAN, U-1317 Inserm - U-1341 Inrae - Université de Rennes 1, F-35000 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Labarrière+N%22">Labarrière N</searchLink>; INCIT, Inserm, University of Nantes, CHU Nantes, F-44200 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Ganlonon+L%22">Ganlonon L</searchLink>; Centre de Diagnostic et de Traitement de l'Ulcère de Buruli et de la Lèpre de Pobè, Fondation Raoul Follereau, Pobè, BP 191, 99999 Bénin, France.<br /><searchLink fieldCode="AU" term="%22Adeye+A%22">Adeye A</searchLink>; Centre de Diagnostic et de Traitement de l'Ulcère de Buruli et de la Lèpre de Pobè, Fondation Raoul Follereau, Pobè, BP 191, 99999 Bénin, France.<br /><searchLink fieldCode="AU" term="%22Marion+E%22">Marion E</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Dubee+V%22">Dubee V</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.; Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire d'Angers, F-49933 Angers, France.<br /><searchLink fieldCode="AU" term="%22Pedrosa+J%22">Pedrosa J</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Yeramian+E%22">Yeramian E</searchLink>; Unité de Microbiologie Structurale, Institut Pasteur, CNRS, University Paris Cité, F-75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Marsollier+L%22">Marsollier L</searchLink>; INCIT, Inserm, University of Angers, CHU Angers, F-49100 Angers, France.
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