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First-Line Zongertinib in Advanced HER2-Mutant Non-Small-Cell Lung Cancer.

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Title: First-Line Zongertinib in Advanced HER2-Mutant Non-Small-Cell Lung Cancer.
Authors: Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston., Yamamoto N; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo., Girard N; Institut Curie, Institut du Thorax Curie-Montsouris, Paris.; Paris-Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France., Ruiter G; Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam.; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam., Smit EF; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam.; Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, the Netherlands., Planchard D; Department of Medical Oncology, Institut Gustave Roussy, Thoracic Group and International Center for Thoracic Cancers, Villejuif, France.; Faculty of Medicine, Paris-Saclay University, Paris., Nadal E; Thoracic Tumors Unit, Medical Oncology, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona., Wu YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Zugazagoitia J; Department of Medical Oncology, 12 de Octubre Hospital, Madrid., Tu HY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Baik CS; Thoracic, Head and Neck Medical Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle., Yoh K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Soo RA; Department of Hematology-Oncology, National University Cancer Institute, Singapore., Zhao Y; Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China., Sabari JK; Division of Medical Oncology, Perlmutter Cancer Center, New York University Langone Health, New York., Wermke M; National Center for Tumor Diseases-University Cancer Center Early Clinical Trial Unit, Technische Universität Dresden, Dresden, Germany., Scheffler M; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Ahn MJ; Department of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Fernamberg K; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT., Schroeter L; Boehringer Ingelheim Pharma, Biberach an der Riss, Germany., Sadrolhefazi B; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT., Thamer C; Boehringer Ingelheim Pharma, Biberach an der Riss, Germany., Eigenbrod-Giese S; Boehringer Ingelheim International, Ingelheim am Rhein, Germany., Popat S; Lung Unit, Royal Marsden Hospital, London.; Division of Clinical Studies, Institute of Cancer Research, London.
Corporate Authors: Beamion LUNG-1 Investigators
Source: The New England journal of medicine [N Engl J Med] 2026 Apr 30; Vol. 394 (17), pp. 1675-1684. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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  Data: First-Line Zongertinib in Advanced HER2-Mutant Non-Small-Cell Lung Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Heymach+JV%22">Heymach JV</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston.<br /><searchLink fieldCode="AU" term="%22Yamamoto+N%22">Yamamoto N</searchLink>; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo.<br /><searchLink fieldCode="AU" term="%22Girard+N%22">Girard N</searchLink>; Institut Curie, Institut du Thorax Curie-Montsouris, Paris.; Paris-Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France.<br /><searchLink fieldCode="AU" term="%22Ruiter+G%22">Ruiter G</searchLink>; Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam.; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam.<br /><searchLink fieldCode="AU" term="%22Smit+EF%22">Smit EF</searchLink>; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam.; Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Planchard+D%22">Planchard D</searchLink>; Department of Medical Oncology, Institut Gustave Roussy, Thoracic Group and International Center for Thoracic Cancers, Villejuif, France.; Faculty of Medicine, Paris-Saclay University, Paris.<br /><searchLink fieldCode="AU" term="%22Nadal+E%22">Nadal E</searchLink>; Thoracic Tumors Unit, Medical Oncology, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona.<br /><searchLink fieldCode="AU" term="%22Wu+YL%22">Wu YL</searchLink>; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zugazagoitia+J%22">Zugazagoitia J</searchLink>; Department of Medical Oncology, 12 de Octubre Hospital, Madrid.<br /><searchLink fieldCode="AU" term="%22Tu+HY%22">Tu HY</searchLink>; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Baik+CS%22">Baik CS</searchLink>; Thoracic, Head and Neck Medical Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Yoh+K%22">Yoh K</searchLink>; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Soo+RA%22">Soo RA</searchLink>; Department of Hematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Sabari+JK%22">Sabari JK</searchLink>; Division of Medical Oncology, Perlmutter Cancer Center, New York University Langone Health, New York.<br /><searchLink fieldCode="AU" term="%22Wermke+M%22">Wermke M</searchLink>; National Center for Tumor Diseases-University Cancer Center Early Clinical Trial Unit, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Scheffler+M%22">Scheffler M</searchLink>; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ahn+MJ%22">Ahn MJ</searchLink>; Department of Hematology and Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Fernamberg+K%22">Fernamberg K</searchLink>; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT.<br /><searchLink fieldCode="AU" term="%22Schroeter+L%22">Schroeter L</searchLink>; Boehringer Ingelheim Pharma, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Sadrolhefazi+B%22">Sadrolhefazi B</searchLink>; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT.<br /><searchLink fieldCode="AU" term="%22Thamer+C%22">Thamer C</searchLink>; Boehringer Ingelheim Pharma, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Eigenbrod-Giese+S%22">Eigenbrod-Giese S</searchLink>; Boehringer Ingelheim International, Ingelheim am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22Popat+S%22">Popat S</searchLink>; Lung Unit, Royal Marsden Hospital, London.; Division of Clinical Studies, Institute of Cancer Research, London.
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  Data: <searchLink fieldCode="JN" term="%220255562%22">The New England journal of medicine</searchLink> [N Engl J Med] 2026 Apr 30; Vol. 394 (17), pp. 1675-1684. <i>Date of Electronic Publication: </i>2026 Apr 15.
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