PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma.
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| Title: | PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma. |
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| Authors: | Onishi S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Jayamohan S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA., Chowdhury A; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Rivas S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Otani Y; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Ertekin C; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bryant JP; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Murphy SA; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Rivera-Caraballo KA; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Walbridge S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sisay B; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Maric D; Flow and Imaging Cytometry Core Facility, NINDS, NIH, Bethesda, MD, USA., Elkahloun A; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Johnson K; Bioinformatics Core, Information Technology Program, NINDS, NIH, Bethesda, MD, USA., Brown DA; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Heiss JD; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Shah AH; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lee TJ; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Kumbar SG; Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Omaha, NE, USA., Yoo JY; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Kaur B; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Banasavadi-Siddegowda YK; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. yesh.banasavadisiddegowda@nih.gov. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 15; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41986321 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Onishi+S%22">Onishi S</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jayamohan+S%22">Jayamohan S</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+A%22">Chowdhury A</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rivas+S%22">Rivas S</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Otani+Y%22">Otani Y</searchLink>; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ertekin+C%22">Ertekin C</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bryant+JP%22">Bryant JP</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+SA%22">Murphy SA</searchLink>; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rivera-Caraballo+KA%22">Rivera-Caraballo KA</searchLink>; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Walbridge+S%22">Walbridge S</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sisay+B%22">Sisay B</searchLink>; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Maric+D%22">Maric D</searchLink>; Flow and Imaging Cytometry Core Facility, NINDS, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Elkahloun+A%22">Elkahloun A</searchLink>; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+K%22">Johnson K</searchLink>; Bioinformatics Core, Information Technology Program, NINDS, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brown+DA%22">Brown DA</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Heiss+JD%22">Heiss JD</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shah+AH%22">Shah AH</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lee+TJ%22">Lee TJ</searchLink>; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kumbar+SG%22">Kumbar SG</searchLink>; Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Yoo+JY%22">Yoo JY</searchLink>; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+AJ%22">Brenner AJ</searchLink>; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+B%22">Kaur B</searchLink>; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sareddy+GR%22">Sareddy GR</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Banasavadi-Siddegowda+YK%22">Banasavadi-Siddegowda YK</searchLink>; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. yesh.banasavadisiddegowda@nih.gov. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Apr 15; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41986321 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-026-08739-5 Languages: – Code: eng Text: English Titles: – TitleFull: PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Onishi S – PersonEntity: Name: NameFull: Jayamohan S – PersonEntity: Name: NameFull: Chowdhury A – PersonEntity: Name: NameFull: Rivas S – PersonEntity: Name: NameFull: Otani Y – PersonEntity: Name: NameFull: Ertekin C – PersonEntity: Name: NameFull: Bryant JP – PersonEntity: Name: NameFull: Murphy SA – PersonEntity: Name: NameFull: Rivera-Caraballo KA – PersonEntity: Name: NameFull: Walbridge S – PersonEntity: Name: NameFull: Sisay B – PersonEntity: Name: NameFull: Maric D – PersonEntity: Name: NameFull: Elkahloun A – PersonEntity: Name: NameFull: Johnson K – PersonEntity: Name: NameFull: Brown DA – PersonEntity: Name: NameFull: Heiss JD – PersonEntity: Name: NameFull: Shah AH – PersonEntity: Name: NameFull: Lee TJ – PersonEntity: Name: NameFull: Kumbar SG – PersonEntity: Name: NameFull: Yoo JY – PersonEntity: Name: NameFull: Brenner AJ – PersonEntity: Name: NameFull: Kaur B – PersonEntity: Name: NameFull: Sareddy GR – PersonEntity: Name: NameFull: Banasavadi-Siddegowda YK IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 04 Text: 2026 Apr 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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