PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma.
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| Title: | PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma. |
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| Authors: | Onishi S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Jayamohan S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA., Chowdhury A; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Rivas S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Otani Y; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Ertekin C; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bryant JP; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Murphy SA; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Rivera-Caraballo KA; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Walbridge S; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sisay B; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Maric D; Flow and Imaging Cytometry Core Facility, NINDS, NIH, Bethesda, MD, USA., Elkahloun A; Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Johnson K; Bioinformatics Core, Information Technology Program, NINDS, NIH, Bethesda, MD, USA., Brown DA; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Heiss JD; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Shah AH; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lee TJ; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Kumbar SG; Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Omaha, NE, USA., Yoo JY; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA., Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Kaur B; Georgia Cancer Center, Augusta University Medical Center, Augusta, GA, USA., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Banasavadi-Siddegowda YK; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. yesh.banasavadisiddegowda@nih.gov. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 15; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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