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Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.

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Title: Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.
Authors: Rydbirk R; Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Sørensen FNF; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., Folke J; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Haukedal H; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark., Martinez AA; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., Vargas IL; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., McGarry S; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., Hollmann OC; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., Gherardelli C; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA., Sepulveda S; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA., Szafran AT; Department of Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Mancini MA; Department of Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Kaalund SS; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Brudek T; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Salvesen L; Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Bech S; Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark., Okarmus J; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Kharchenko P; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Meyer M; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Soto C; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA., Freude K; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark., Mukherjee A; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA., Aznar S; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark. Susana.aznar.kleijn@regionh.dk.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark. Susana.aznar.kleijn@regionh.dk., Khodosevich K; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark. konstantin.khodosevich@bric.ku.dk.
Source: Nature communications [Nat Commun] 2026 Apr 15; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.
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  Data: <searchLink fieldCode="AU" term="%22Rydbirk+R%22">Rydbirk R</searchLink>; Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+FNF%22">Sørensen FNF</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.<br /><searchLink fieldCode="AU" term="%22Folke+J%22">Folke J</searchLink>; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Haukedal+H%22">Haukedal H</searchLink>; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.<br /><searchLink fieldCode="AU" term="%22Martinez+AA%22">Martinez AA</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.<br /><searchLink fieldCode="AU" term="%22Vargas+IL%22">Vargas IL</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.<br /><searchLink fieldCode="AU" term="%22McGarry+S%22">McGarry S</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.<br /><searchLink fieldCode="AU" term="%22Hollmann+OC%22">Hollmann OC</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.<br /><searchLink fieldCode="AU" term="%22Gherardelli+C%22">Gherardelli C</searchLink>; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Sepulveda+S%22">Sepulveda S</searchLink>; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Szafran+AT%22">Szafran AT</searchLink>; Department of Molecular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mancini+MA%22">Mancini MA</searchLink>; Department of Molecular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kaalund+SS%22">Kaalund SS</searchLink>; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Brudek+T%22">Brudek T</searchLink>; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Salvesen+L%22">Salvesen L</searchLink>; Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Bech+S%22">Bech S</searchLink>; Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark.<br /><searchLink fieldCode="AU" term="%22Okarmus+J%22">Okarmus J</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Kharchenko+P%22">Kharchenko P</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Soto+C%22">Soto C</searchLink>; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Freude+K%22">Freude K</searchLink>; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.<br /><searchLink fieldCode="AU" term="%22Mukherjee+A%22">Mukherjee A</searchLink>; Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Aznar+S%22">Aznar S</searchLink>; Center for Neuroscience and Stereology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark. Susana.aznar.kleijn@regionh.dk.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen NV, Denmark. Susana.aznar.kleijn@regionh.dk.<br /><searchLink fieldCode="AU" term="%22Khodosevich+K%22">Khodosevich K</searchLink>; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark. konstantin.khodosevich@bric.ku.dk.
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