View in EDS HTML Full Text PDF Full Text

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.

Saved in:
Bibliographic Details
Title: Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
Authors: Su Y; Institute for Systems Biology, Seattle, WA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Liu C; Institute for Systems Biology, Seattle, WA, USA., Lu X; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Key Laboratory of Agricultural Bioinformatics (Ministry of Education), Sichuan Agricultural University, Chengdu, China., Chuang HY; Institute for Systems Biology, Seattle, WA, USA., Li G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Shao S; Institute for Systems Biology, Seattle, WA, USA., Kong Y; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China., Lee JW; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Ng RH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Wong S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Robert L; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA., Warden C; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Liu V; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Chen J; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China., Wang Z; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China., Qin G; Institute for Systems Biology, Seattle, WA, USA., Tang Y; Institute for Systems Biology, Seattle, WA, USA., Cheng H; Institute for Systems Biology, Seattle, WA, USA., Ng AHC; Institute for Systems Biology, Seattle, WA, USA., Chen D; Institute for Systems Biology, Seattle, WA, USA., Peng S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Xue M; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Johnson D; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA., Xu Y; Fudan University Shanghai Cancer Center, Shanghai, China., Wang J; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Wu X; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Shmulevich I; Institute for Systems Biology, Seattle, WA, USA., Shi Q; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China., Levine R; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; The Fritz Haber Research Center, The Hebrew University, Jerusalem, Israel., Ribas A; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Surgery, University of California-Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA., Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Guo J; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China., Heath JR; Institute for Systems Biology, Seattle, WA, USA. jheath@systemsbiology.org.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. jheath@systemsbiology.org., Wei W; Institute for Systems Biology, Seattle, WA, USA. wwei@systemsbiology.org.; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org.
Source: Nature communications [Nat Commun] 2026 Apr 15; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41986344
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Institute for Systems Biology, Seattle, WA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Key Laboratory of Agricultural Bioinformatics (Ministry of Education), Sichuan Agricultural University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Chuang+HY%22">Chuang HY</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shao+S%22">Shao S</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+Y%22">Kong Y</searchLink>; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ng+RH%22">Ng RH</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+S%22">Wong S</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Robert+L%22">Robert L</searchLink>; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Warden+C%22">Warden C</searchLink>; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+V%22">Liu V</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qin+G%22">Qin G</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ng+AHC%22">Ng AHC</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Peng+S%22">Peng S</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xue+M%22">Xue M</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+D%22">Johnson D</searchLink>; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shmulevich+I%22">Shmulevich I</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Levine+R%22">Levine R</searchLink>; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; The Fritz Haber Research Center, The Hebrew University, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Ribas+A%22">Ribas A</searchLink>; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Surgery, University of California-Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Baltimore+D%22">Baltimore D</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Heath+JR%22">Heath JR</searchLink>; Institute for Systems Biology, Seattle, WA, USA. jheath@systemsbiology.org.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. jheath@systemsbiology.org.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Institute for Systems Biology, Seattle, WA, USA. wwei@systemsbiology.org.; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Apr 15; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 15.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41986344
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-71349-4
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Su Y
      – PersonEntity:
          Name:
            NameFull: Liu C
      – PersonEntity:
          Name:
            NameFull: Lu X
      – PersonEntity:
          Name:
            NameFull: Chuang HY
      – PersonEntity:
          Name:
            NameFull: Li G
      – PersonEntity:
          Name:
            NameFull: Shao S
      – PersonEntity:
          Name:
            NameFull: Kong Y
      – PersonEntity:
          Name:
            NameFull: Lee JW
      – PersonEntity:
          Name:
            NameFull: Ng RH
      – PersonEntity:
          Name:
            NameFull: Wong S
      – PersonEntity:
          Name:
            NameFull: Robert L
      – PersonEntity:
          Name:
            NameFull: Warden C
      – PersonEntity:
          Name:
            NameFull: Liu V
      – PersonEntity:
          Name:
            NameFull: Chen J
      – PersonEntity:
          Name:
            NameFull: Wang Z
      – PersonEntity:
          Name:
            NameFull: Qin G
      – PersonEntity:
          Name:
            NameFull: Tang Y
      – PersonEntity:
          Name:
            NameFull: Cheng H
      – PersonEntity:
          Name:
            NameFull: Ng AHC
      – PersonEntity:
          Name:
            NameFull: Chen D
      – PersonEntity:
          Name:
            NameFull: Peng S
      – PersonEntity:
          Name:
            NameFull: Xue M
      – PersonEntity:
          Name:
            NameFull: Johnson D
      – PersonEntity:
          Name:
            NameFull: Xu Y
      – PersonEntity:
          Name:
            NameFull: Wang J
      – PersonEntity:
          Name:
            NameFull: Wu X
      – PersonEntity:
          Name:
            NameFull: Shmulevich I
      – PersonEntity:
          Name:
            NameFull: Shi Q
      – PersonEntity:
          Name:
            NameFull: Levine R
      – PersonEntity:
          Name:
            NameFull: Ribas A
      – PersonEntity:
          Name:
            NameFull: Baltimore D
      – PersonEntity:
          Name:
            NameFull: Guo J
      – PersonEntity:
          Name:
            NameFull: Heath JR
      – PersonEntity:
          Name:
            NameFull: Wei W
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 04
              Text: 2026 Apr 15
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1