Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
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| Title: | Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer. |
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| Authors: | Su Y; Institute for Systems Biology, Seattle, WA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Liu C; Institute for Systems Biology, Seattle, WA, USA., Lu X; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Key Laboratory of Agricultural Bioinformatics (Ministry of Education), Sichuan Agricultural University, Chengdu, China., Chuang HY; Institute for Systems Biology, Seattle, WA, USA., Li G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Shao S; Institute for Systems Biology, Seattle, WA, USA., Kong Y; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China., Lee JW; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Ng RH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Wong S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Robert L; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA., Warden C; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Liu V; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Chen J; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China., Wang Z; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China., Qin G; Institute for Systems Biology, Seattle, WA, USA., Tang Y; Institute for Systems Biology, Seattle, WA, USA., Cheng H; Institute for Systems Biology, Seattle, WA, USA., Ng AHC; Institute for Systems Biology, Seattle, WA, USA., Chen D; Institute for Systems Biology, Seattle, WA, USA., Peng S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Xue M; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Johnson D; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA., Xu Y; Fudan University Shanghai Cancer Center, Shanghai, China., Wang J; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Wu X; Department of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA., Shmulevich I; Institute for Systems Biology, Seattle, WA, USA., Shi Q; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China., Levine R; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; The Fritz Haber Research Center, The Hebrew University, Jerusalem, Israel., Ribas A; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.; Department of Surgery, University of California-Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA., Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Guo J; The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China., Heath JR; Institute for Systems Biology, Seattle, WA, USA. jheath@systemsbiology.org.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. jheath@systemsbiology.org., Wei W; Institute for Systems Biology, Seattle, WA, USA. wwei@systemsbiology.org.; Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org.; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA. wwei@systemsbiology.org. |
| Source: | Nature communications [Nat Commun] 2026 Apr 15; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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