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Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.

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Title: Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.
Authors: Bandesh K; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Motakis E; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Nargund S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Kursawe R; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Selvam V; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Ansarullah; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA., Bhuiyan RM; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA., Eryilmaz GN; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Willett AM; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA., White JK; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA., Krishnan SN; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA., Spracklen CN; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Ucar D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.; Institute for Systems Genomics, UConn, Farmington, CT, USA., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. michael.stitzel@jax.org.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. michael.stitzel@jax.org.; Institute for Systems Genomics, UConn, Farmington, CT, USA. michael.stitzel@jax.org.
Source: The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (11), pp. 3978-4005. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.
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  Data: <searchLink fieldCode="AU" term="%22Bandesh+K%22">Bandesh K</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Motakis+E%22">Motakis E</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nargund+S%22">Nargund S</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kursawe+R%22">Kursawe R</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Selvam+V%22">Selvam V</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Ansarullah%22">Ansarullah</searchLink>; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Bhuiyan+RM%22">Bhuiyan RM</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Eryilmaz+GN%22">Eryilmaz GN</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Willett+AM%22">Willett AM</searchLink>; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22White+JK%22">White JK</searchLink>; The Jackson Laboratory, Center for Biometric Analysis (CBA), Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Krishnan+SN%22">Krishnan SN</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Spracklen+CN%22">Spracklen CN</searchLink>; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ucar+D%22">Ucar D</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.; Institute for Systems Genomics, UConn, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Stitzel+ML%22">Stitzel ML</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. michael.stitzel@jax.org.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. michael.stitzel@jax.org.; Institute for Systems Genomics, UConn, Farmington, CT, USA. michael.stitzel@jax.org.
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              Text: 2026 Jun
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