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SETD8 promotes ovarian clear cell carcinoma by epigenetically activating RNA metabolism genes via H4K20me1.

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Title: SETD8 promotes ovarian clear cell carcinoma by epigenetically activating RNA metabolism genes via H4K20me1.
Authors: Suzuki-Ariyoshi E; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Kaneko S; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. sykaneko@ncc.go.jp.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan. sykaneko@ncc.go.jp., Sone K; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan. ksone5274@gmail.com., Ikawa N; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan., Hachijo R; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Jonouchi Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Tsuboyama N; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Taguchi A; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Asada K; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan., Komatsu M; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan., Iriyama T; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Oda K; Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Osuga Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Hirota Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan., Hamamoto R; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan.
Source: Scientific reports [Sci Rep] 2026 Apr 15; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
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  Data: SETD8 promotes ovarian clear cell carcinoma by epigenetically activating RNA metabolism genes via H4K20me1.
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  Data: <searchLink fieldCode="AU" term="%22Suzuki-Ariyoshi+E%22">Suzuki-Ariyoshi E</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+S%22">Kaneko S</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. sykaneko@ncc.go.jp.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan. sykaneko@ncc.go.jp.<br /><searchLink fieldCode="AU" term="%22Sone+K%22">Sone K</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan. ksone5274@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ikawa+N%22">Ikawa N</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Hachijo+R%22">Hachijo R</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Jonouchi+Y%22">Jonouchi Y</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuboyama+N%22">Tsuboyama N</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+A%22">Taguchi A</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Asada+K%22">Asada K</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan.<br /><searchLink fieldCode="AU" term="%22Komatsu+M%22">Komatsu M</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan.<br /><searchLink fieldCode="AU" term="%22Iriyama+T%22">Iriyama T</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Oda+K%22">Oda K</searchLink>; Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Osuga+Y%22">Osuga Y</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Hirota+Y%22">Hirota Y</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Hamamoto+R%22">Hamamoto R</searchLink>; Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.; AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan.
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