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Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.

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Title: Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.
Authors: Adkinson BD; Yale School of Medicine, New Haven, CT, USA. brendan.adkinson@yale.edu., Rosenblatt M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Sun H; Yale School of Medicine, New Haven, CT, USA., Dadashkarimi J; Department of Radiology, Perelman School of Medicine, Philadelphia, PA, USA., Tejavibulya L; Yale School of Medicine, New Haven, CT, USA., Horien C; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Westwater ML; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK., Rodriguez RX; Yale School of Medicine, New Haven, CT, USA., Noble S; Department of Bioengineering, Northeastern University, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.; Institute for Cognitive & Behavioral Health, Northeastern University, Boston, MA, USA., Scheinost D; Yale School of Medicine, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Department of Statistics & Data Science, Yale University, New Haven, CT, USA.; Child Study Center, Yale School of Medicine, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.
Source: Nature human behaviour [Nat Hum Behav] 2026 Apr 15. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Publishing Country of Publication: England NLM ID: 101697750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3374 (Electronic) Linking ISSN: 23973374 NLM ISO Abbreviation: Nat Hum Behav Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Adkinson+BD%22">Adkinson BD</searchLink>; Yale School of Medicine, New Haven, CT, USA. brendan.adkinson@yale.edu.<br /><searchLink fieldCode="AU" term="%22Rosenblatt+M%22">Rosenblatt M</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Dadashkarimi+J%22">Dadashkarimi J</searchLink>; Department of Radiology, Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tejavibulya+L%22">Tejavibulya L</searchLink>; Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Horien+C%22">Horien C</searchLink>; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Westwater+ML%22">Westwater ML</searchLink>; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rodriguez+RX%22">Rodriguez RX</searchLink>; Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Noble+S%22">Noble S</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.; Institute for Cognitive & Behavioral Health, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scheinost+D%22">Scheinost D</searchLink>; Yale School of Medicine, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.; Department of Statistics & Data Science, Yale University, New Haven, CT, USA.; Child Study Center, Yale School of Medicine, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.
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