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Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.

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Title: Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.
Authors: Rathgeber AC; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany., Fernandes SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nagler A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Li S; Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA., Dorfman DM; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bullinger L; Department of Hematology, Oncology, and Cancer Immunology, Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site Berlin, Berlin, Germany., Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Livak KJ; Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA., Ludwig LS; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA.; Harvard Medical School, Boston, USA., Penter L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. livius.penter@charite.de.; Department of Hematology, Oncology, and Cancer Immunology, Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Germany. livius.penter@charite.de.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. livius.penter@charite.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany. livius.penter@charite.de.
Source: Genome biology [Genome Biol] 2026 Apr 15; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Rathgeber+AC%22">Rathgeber AC</searchLink>; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fernandes+SM%22">Fernandes SM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nagler+A%22">Nagler A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA.<br /><searchLink fieldCode="AU" term="%22Dorfman+DM%22">Dorfman DM</searchLink>; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bullinger+L%22">Bullinger L</searchLink>; Department of Hematology, Oncology, and Cancer Immunology, Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Davids+MS%22">Davids MS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JR%22">Brown JR</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Livak+KJ%22">Livak KJ</searchLink>; Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ludwig+LS%22">Ludwig LS</searchLink>; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+CJ%22">Wu CJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Penter+L%22">Penter L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. livius.penter@charite.de.; Department of Hematology, Oncology, and Cancer Immunology, Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Germany. livius.penter@charite.de.; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. livius.penter@charite.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany. livius.penter@charite.de.
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  Data: <searchLink fieldCode="JN" term="%22100960660%22">Genome biology</searchLink> [Genome Biol] 2026 Apr 15; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Apr 15.
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