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Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk.

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Title: Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk.
Authors: Poore HE; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA., Chatzinakos C; Department of Psychiatry and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, NY USA., Leger B; Department of Psychiatry, University of California San Diego, La Jolla, CA USA., Gonzalez J; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA., Mallard TT; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA USA.; Department of Psychiatry, Harvard Medical School, Cambridge, MA USA., Aliev F; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA., Hatoum A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO USA., Waldman ID; Department of Psychology, Emory University, Atlanta, GA USA., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA., Harden KP; Department of Psychology, University of Texas at Austin, Austin, TX USA.; Population Research Center, University of Texas at Austin, Austin, TX USA., Dick DM; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA., Barr PB; Department of Psychiatry and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, NY USA.
Source: Nature. Mental health [Nat Ment Health] 2026; Vol. 4 (4), pp. 582-593. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918486688806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-6076 (Electronic) Linking ISSN: 27316076 NLM ISO Abbreviation: Nat Ment Health Subsets: PubMed not MEDLINE
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  Data: Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk.
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  Data: <searchLink fieldCode="AU" term="%22Poore+HE%22">Poore HE</searchLink>; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA.<br /><searchLink fieldCode="AU" term="%22Chatzinakos+C%22">Chatzinakos C</searchLink>; Department of Psychiatry and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, NY USA.<br /><searchLink fieldCode="AU" term="%22Leger+B%22">Leger B</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+J%22">Gonzalez J</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA.<br /><searchLink fieldCode="AU" term="%22Mallard+TT%22">Mallard TT</searchLink>; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA USA.; Department of Psychiatry, Harvard Medical School, Cambridge, MA USA.<br /><searchLink fieldCode="AU" term="%22Aliev+F%22">Aliev F</searchLink>; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA.<br /><searchLink fieldCode="AU" term="%22Hatoum+A%22">Hatoum A</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO USA.<br /><searchLink fieldCode="AU" term="%22Waldman+ID%22">Waldman ID</searchLink>; Department of Psychology, Emory University, Atlanta, GA USA.<br /><searchLink fieldCode="AU" term="%22Sanchez-Roige+S%22">Sanchez-Roige S</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN USA.<br /><searchLink fieldCode="AU" term="%22Palmer+AA%22">Palmer AA</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA USA.<br /><searchLink fieldCode="AU" term="%22Harden+KP%22">Harden KP</searchLink>; Department of Psychology, University of Texas at Austin, Austin, TX USA.; Population Research Center, University of Texas at Austin, Austin, TX USA.<br /><searchLink fieldCode="AU" term="%22Dick+DM%22">Dick DM</searchLink>; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA.<br /><searchLink fieldCode="AU" term="%22Barr+PB%22">Barr PB</searchLink>; Department of Psychiatry and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, NY USA.
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  Data: <searchLink fieldCode="JN" term="%229918486688806676%22">Nature. Mental health</searchLink> [Nat Ment Health] 2026; Vol. 4 (4), pp. 582-593. <i>Date of Electronic Publication: </i>2026 Mar 20.
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