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Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU).

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Title: Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU).
Authors: Dépret F; Université Paris Cité, Paris, France depret.francois@gmail.com.; Department of Anesthesiology, Surgical Critical Care and Burn Unit, Assistance Publique - Hopitaux de Paris, Paris, France.; INI-CRCT, Nancy, France., Chousterman B; INI-CRCT, Nancy, France.; Université Paris Cité, INSERM U942 MASCOT, Paris, France.; Department of Anesthesia and Critical Care, AP-HP, Hôpital Lariboisière, Paris, France., Roger C; Division of Anesthesia and Critical Care, Pain and Emergency Medicine, UR-UM103 IMAGINE, University Montpellier, Nîmes University Hospital, Nimes, France., Garnier M; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Lalande R; Medico-Surgical Intensive Care Unit, CHU Clermont-Ferrand, Clermont-Ferrand, France., Kerforne T; Department of Anesthesiology and Critical Care, CHU de Poitiers, Poitiers, France., Rouve E; Critical Care Unit, CH Perpignan, Perpignan, France., Lukaszewicz AC; Department of Anesthesiology and Critical Care, Hospices Civils de Lyon, Lyon, France., Ouattara A; Department of Cardiovascular Anesthesia and Critical Care, CHU Bordeaux, University Hospital of Bordeaux, INSERM, Biologie des maladies cardiovasculaires, Bordeaux, France., Merdji H; Medical Critical Care, CHU de Strasbourg, Strasbourg, France., Turbil E; Critical Care Unit, CH Aurillac, Aurillac, France., Bouhemad B; Centre Hospitalier Universitaire de Dijon Pole Anesthesie Reanimations Chirurgicales Urgences et Medecine legale, Dijon, France., Quenot JP; Université Bourgogne-Europe, INSERM, CTM 1231, Equipe Lipness, Service de Médecine Intensive-Réanimation, Dijon, France., Delbove A; Réanimation Polyvalente, Centre Hospitalier Bretagne Atlantique, Vannes, France., Levrat Q; Critical Care Unit, CH La Rochelle, La Rochelle, France., Jully M; Critical Care Unit, CH d Antibes Juan les Pins, Antibes, France., Legriel S; Intensive Care Unit, Centre Hospitalier de Versailles, Le Chesnay, France., Bougouin W; Medico-Surgical Critical Care, Hôpital Privé Jacques Cartier, Massy, France., Klouche K; Intensive Care, Universite de Montpellier, Montpellier, France., Kimmoun A; Medical Critical Care, CHRU Nancy, Nancy, France., Asfar P; Medical Critical Care, CHU Angers, Angers, France., Vicaut E; Univeristé Paris Cité, INSERM U942 MSCOT, Paris, France.; Unité de recherche Clinique, Lariboisière, Saint-Louis, Fernand Widal, Paris, France., Mebazaa A; Université Paris Cité, INSERM U942 MASCOT, Paris, France.; Department of Anesthesia and Critical Care, AP-HP, Hôpital Lariboisière, Paris, France.; Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, Paris, France.
Source: BMJ open [BMJ Open] 2026 Apr 16; Vol. 16 (4), pp. e108119. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU).
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  Data: <searchLink fieldCode="AU" term="%22Dépret+F%22">Dépret F</searchLink>; Université Paris Cité, Paris, France depret.francois@gmail.com.; Department of Anesthesiology, Surgical Critical Care and Burn Unit, Assistance Publique - Hopitaux de Paris, Paris, France.; INI-CRCT, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Chousterman+B%22">Chousterman B</searchLink>; INI-CRCT, Nancy, France.; Université Paris Cité, INSERM U942 MASCOT, Paris, France.; Department of Anesthesia and Critical Care, AP-HP, Hôpital Lariboisière, Paris, France.<br /><searchLink fieldCode="AU" term="%22Roger+C%22">Roger C</searchLink>; Division of Anesthesia and Critical Care, Pain and Emergency Medicine, UR-UM103 IMAGINE, University Montpellier, Nîmes University Hospital, Nimes, France.<br /><searchLink fieldCode="AU" term="%22Garnier+M%22">Garnier M</searchLink>; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Lalande+R%22">Lalande R</searchLink>; Medico-Surgical Intensive Care Unit, CHU Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Kerforne+T%22">Kerforne T</searchLink>; Department of Anesthesiology and Critical Care, CHU de Poitiers, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Rouve+E%22">Rouve E</searchLink>; Critical Care Unit, CH Perpignan, Perpignan, France.<br /><searchLink fieldCode="AU" term="%22Lukaszewicz+AC%22">Lukaszewicz AC</searchLink>; Department of Anesthesiology and Critical Care, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ouattara+A%22">Ouattara A</searchLink>; Department of Cardiovascular Anesthesia and Critical Care, CHU Bordeaux, University Hospital of Bordeaux, INSERM, Biologie des maladies cardiovasculaires, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Merdji+H%22">Merdji H</searchLink>; Medical Critical Care, CHU de Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Turbil+E%22">Turbil E</searchLink>; Critical Care Unit, CH Aurillac, Aurillac, France.<br /><searchLink fieldCode="AU" term="%22Bouhemad+B%22">Bouhemad B</searchLink>; Centre Hospitalier Universitaire de Dijon Pole Anesthesie Reanimations Chirurgicales Urgences et Medecine legale, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Quenot+JP%22">Quenot JP</searchLink>; Université Bourgogne-Europe, INSERM, CTM 1231, Equipe Lipness, Service de Médecine Intensive-Réanimation, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Delbove+A%22">Delbove A</searchLink>; Réanimation Polyvalente, Centre Hospitalier Bretagne Atlantique, Vannes, France.<br /><searchLink fieldCode="AU" term="%22Levrat+Q%22">Levrat Q</searchLink>; Critical Care Unit, CH La Rochelle, La Rochelle, France.<br /><searchLink fieldCode="AU" term="%22Jully+M%22">Jully M</searchLink>; Critical Care Unit, CH d Antibes Juan les Pins, Antibes, France.<br /><searchLink fieldCode="AU" term="%22Legriel+S%22">Legriel S</searchLink>; Intensive Care Unit, Centre Hospitalier de Versailles, Le Chesnay, France.<br /><searchLink fieldCode="AU" term="%22Bougouin+W%22">Bougouin W</searchLink>; Medico-Surgical Critical Care, Hôpital Privé Jacques Cartier, Massy, France.<br /><searchLink fieldCode="AU" term="%22Klouche+K%22">Klouche K</searchLink>; Intensive Care, Universite de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Kimmoun+A%22">Kimmoun A</searchLink>; Medical Critical Care, CHRU Nancy, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Asfar+P%22">Asfar P</searchLink>; Medical Critical Care, CHU Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Vicaut+E%22">Vicaut E</searchLink>; Univeristé Paris Cité, INSERM U942 MSCOT, Paris, France.; Unité de recherche Clinique, Lariboisière, Saint-Louis, Fernand Widal, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mebazaa+A%22">Mebazaa A</searchLink>; Université Paris Cité, INSERM U942 MASCOT, Paris, France.; Department of Anesthesia and Critical Care, AP-HP, Hôpital Lariboisière, Paris, France.; Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, Paris, France.
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