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Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial.

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Title: Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial.
Authors: Grohar PJ; Division of Pediatric Hematology/Oncology, University of Michigan Medical School, C.S. Mott Children's Hospital, Rogel Cancer Center, Ann Arbor, MI, USA. grohar@med.umich.edu., Heise R; Weill Cornell Medicine, New York, NY, USA., Wedekind MF; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ballman K; Mayo Clinic, Rochester, MN, USA., Mascarenhas L; Guerin Children's and Cedars Sinai Cancer, Cedars Sinai Health Sciences University, Los Angeles, CA, USA., DuBois SG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA., Maki RG; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Boguslawski EA; Division of Pediatric Hematology/Oncology, University of Michigan Medical School, C.S. Mott Children's Hospital, Rogel Cancer Center, Ann Arbor, MI, USA., Gedminas JM; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Wilson ER; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Thomas E; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Segers B; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Surrey LF; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ricker C; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA., Klega K; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA., Navid F; Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lam GY; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., The S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Kaufman R; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Roberts RD; Department of Pediatrics, Center for Childhood Cancer, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Hayashi M; Department of Pediatrics, University of Colorado Anschutz Medical Campus and Center for Cancer and Blood Disorders, Children's Hospital of Colorado, Aurora, CO, USA., Mena E; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Overman L; Sarcoma Alliance for Research through Collaboration, Ann Arbor, MI, USA., Peer C; Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Schmidt K; Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Diamond MS; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Figg WD; Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Bagatell R; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Liza Lindenberg M; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Choyke PL; Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Crompton BD; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA., Widemann BC; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Glod JW; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Laetsch TW; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Reinke DK; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Chugh R; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
Source: Nature medicine [Nat Med] 2026 Jun; Vol. 32 (6), pp. 2227-2237. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial.
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Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Glod+JW%22">Glod JW</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Laetsch+TW%22">Laetsch TW</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Reinke+DK%22">Reinke DK</searchLink>; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chugh+R%22">Chugh R</searchLink>; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
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