Genetic background shapes AI-predicted variant effects.
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| Title: | Genetic background shapes AI-predicted variant effects. |
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| Authors: | Schilder BM; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Liu Z; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Desmarais JJ; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Laub D; Division of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA., Rahimi F; Department of Biology, University of Florida, Gainesville, FL, USA., Sethi P; Department of Biology, University of Florida, Gainesville, FL, USA., Pereira LA; Department of Biology, University of Florida, Gainesville, FL, USA., Sun M; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Kinney JB; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., McCandlish DM; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zhou J; Department of Biology, University of Florida, Gainesville, FL, USA., Koo PK; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 07. Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41993283 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genetic background shapes AI-predicted variant effects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Schilder+BM%22">Schilder BM</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Desmarais+JJ%22">Desmarais JJ</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Laub+D%22">Laub D</searchLink>; Division of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rahimi+F%22">Rahimi F</searchLink>; Department of Biology, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sethi+P%22">Sethi P</searchLink>; Department of Biology, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+LA%22">Pereira LA</searchLink>; Department of Biology, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sun+M%22">Sun M</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kinney+JB%22">Kinney JB</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22McCandlish+DM%22">McCandlish DM</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Biology, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Koo+PK%22">Koo PK</searchLink>; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Apr 07. <i>Date of Electronic Publication: </i>2026 Apr 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41993283 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.64898/2026.04.04.715328 Languages: – Code: eng Text: English Titles: – TitleFull: Genetic background shapes AI-predicted variant effects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Schilder BM – PersonEntity: Name: NameFull: Liu Z – PersonEntity: Name: NameFull: Desmarais JJ – PersonEntity: Name: NameFull: Laub D – PersonEntity: Name: NameFull: Rahimi F – PersonEntity: Name: NameFull: Sethi P – PersonEntity: Name: NameFull: Pereira LA – PersonEntity: Name: NameFull: Sun M – PersonEntity: Name: NameFull: Kinney JB – PersonEntity: Name: NameFull: McCandlish DM – PersonEntity: Name: NameFull: Zhou J – PersonEntity: Name: NameFull: Koo PK IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 04 Text: 2026 Apr 07 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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