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Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine.

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Title: Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine.
Authors: Singhal R; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Zhang NW; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI., Lee ZH; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Bell HN; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Dalal PJ; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA., Solanki S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Huang W; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA., Rebernick R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Jasewicz H; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI., Kumar R; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA., Kotla NK; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Huber A; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Mallappa AV; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA., Arya SB; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA., Takahashi S; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kasano-Camones CI; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Carpenter E; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Moon JJ; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Parent CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Gonzalez FJ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA., Green MD; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Zou W; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan, Ann Arbor, MI, USA., Stoffel EM; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 06. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine.
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  Data: <searchLink fieldCode="AU" term="%22Singhal+R%22">Singhal R</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+NW%22">Zhang NW</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Lee+ZH%22">Lee ZH</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bell+HN%22">Bell HN</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Dalal+PJ%22">Dalal PJ</searchLink>; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Solanki+S%22">Solanki S</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Rebernick+R%22">Rebernick R</searchLink>; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sajjakulnukit+P%22">Sajjakulnukit P</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Jasewicz+H%22">Jasewicz H</searchLink>; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kotla+NK%22">Kotla NK</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Huber+A%22">Huber A</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Mallappa+AV%22">Mallappa AV</searchLink>; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA.<br /><searchLink fieldCode="AU" term="%22Arya+SB%22">Arya SB</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kasano-Camones+CI%22">Kasano-Camones CI</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Carpenter+E%22">Carpenter E</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22di+Magliano+MP%22">di Magliano MP</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Moon+JJ%22">Moon JJ</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Parent+CA%22">Parent CA</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+FJ%22">Gonzalez FJ</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Patterson+AD%22">Patterson AD</searchLink>; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA.<br /><searchLink fieldCode="AU" term="%22Green+MD%22">Green MD</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zou+W%22">Zou W</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Stoffel+EM%22">Stoffel EM</searchLink>; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lyssiotis+CA%22">Lyssiotis CA</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Shah+YM%22">Shah YM</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
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