Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine.
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| Title: | Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine. |
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| Authors: | Singhal R; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Zhang NW; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI., Lee ZH; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Bell HN; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Dalal PJ; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA., Solanki S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Huang W; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA., Rebernick R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Jasewicz H; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI., Kumar R; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA., Kotla NK; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Huber A; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Mallappa AV; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA., Arya SB; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA., Takahashi S; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kasano-Camones CI; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Carpenter E; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Moon JJ; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Parent CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Gonzalez FJ; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Patterson AD; Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Penn State University, PA, USA., Green MD; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA., Zou W; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan, Ann Arbor, MI, USA., Stoffel EM; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 06. Date of Electronic Publication: 2026 Apr 06. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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