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Viral vector-free generation of orthogonal IL-2-responsive CAR T cells through gene editing of IL-2 and its receptor.

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Title: Viral vector-free generation of orthogonal IL-2-responsive CAR T cells through gene editing of IL-2 and its receptor.
Authors: Zhang Q; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Wu Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Yang J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Zhou K; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Manoharan ENEA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Wentz T; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Su L; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA., Yu A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Wang HY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Bruhn L; Biology and Chemistry, Agilent Technologies, Santa Clara, CA., Steinfeld I; Biology and Chemistry, Agilent Technologies, Santa Clara, CA., Gonzalez N; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Song EZ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Zhang Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Hresko ME; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Ryan DE; Biology and Chemistry, Agilent Technologies, Santa Clara, CA., Engel NW; Department of Pathology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and., Nunez-Cruz S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., June CH; Department of Pathology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and., Garcia KC; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.; Departments of Molecular and Cellular Physiology and Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA., Milone MC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Source: Blood immunology & cellular therapy [Blood Immunol Cell Ther] 2025 Dec; Vol. 1 (3). Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9919050937306676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3050-5976 (Electronic) Linking ISSN: 30505976 NLM ISO Abbreviation: Blood Immunol Cell Ther Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Viral vector-free generation of orthogonal IL-2-responsive CAR T cells through gene editing of IL-2 and its receptor.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Zhou+K%22">Zhou K</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Manoharan+ENEA%22">Manoharan ENEA</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wentz+T%22">Wentz T</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Su+L%22">Su L</searchLink>; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Yu+A%22">Yu A</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Bruhn+L%22">Bruhn L</searchLink>; Biology and Chemistry, Agilent Technologies, Santa Clara, CA.<br /><searchLink fieldCode="AU" term="%22Steinfeld+I%22">Steinfeld I</searchLink>; Biology and Chemistry, Agilent Technologies, Santa Clara, CA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+N%22">Gonzalez N</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Song+EZ%22">Song EZ</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hresko+ME%22">Hresko ME</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Ryan+DE%22">Ryan DE</searchLink>; Biology and Chemistry, Agilent Technologies, Santa Clara, CA.<br /><searchLink fieldCode="AU" term="%22Engel+NW%22">Engel NW</searchLink>; Department of Pathology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.<br /><searchLink fieldCode="AU" term="%22Nunez-Cruz+S%22">Nunez-Cruz S</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Department of Pathology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.<br /><searchLink fieldCode="AU" term="%22Garcia+KC%22">Garcia KC</searchLink>; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.; Departments of Molecular and Cellular Physiology and Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Milone+MC%22">Milone MC</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
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  Data: <searchLink fieldCode="JN" term="%229919050937306676%22">Blood immunology & cellular therapy</searchLink> [Blood Immunol Cell Ther] 2025 Dec; Vol. 1 (3). <i>Date of Electronic Publication: </i>2025 Dec 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9919050937306676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>3050-5976 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2230505976%22">30505976 </searchLink><i>NLM ISO Abbreviation: </i>Blood Immunol Cell Ther <i>Subsets: </i>PubMed not MEDLINE
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