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Combinatorial delivery of low-dose radiotherapy and immunotherapy to patients with immune-excluded tumors enhances CD8+ T cell functionality.

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Title: Combinatorial delivery of low-dose radiotherapy and immunotherapy to patients with immune-excluded tumors enhances CD8+ T cell functionality.
Authors: Ochoa-de-Olza M; University Hospital of Lausanne Lausanne Switzerland., Rayroux N; University Hospital of Lausanne Lausanne Switzerland., Imbimbo M; University Hospital of Lausanne Lausanne Switzerland., Orcurto A; University Hospital of Lausanne Lausanne Switzerland., Fahr N; University Hospital of Lausanne Lausanne Switzerland., Benedetti F; University Hospital of Lausanne Lausanne Switzerland., Dagher J; University of Lausanne Lausanne Switzerland., Spagnol G; University of Padua Padova Italy., Barras D; University Hospital of Lausanne Lausanne, Vaud Switzerland., Ghisoni E; University of Lausanne Lausanne Switzerland., Navarro B; University Hospital of Lausanne Lausanne, Vaud Switzerland., Mulvey A; University Hospital of Lausanne Lausanne Switzerland., Berthold D; University Hospital of Lausanne Lausanne Switzerland., Sarivalasis A; University Hospital of Lausanne Lausanne Switzerland., Zaman K; University Hospital of Lausanne Lausanne Switzerland., Stravodimou A; Centre Hospitalier Universitaire Vaudois Lausanne Switzerland., Digklia A; University Hospital of Lausanne Lausanne Switzerland., Duran R; University Hospital of Lausanne Lausanne, Vaud Switzerland., Dromain C; University Hospital of Lausanne Switzerland., Prior JO; University Hospital of Lausanne Lausanne, VD Switzerland., Schaefer N; University Hospital of Lausanne Switzerland., Zimmermann S; University Hospital of Lausanne Lausanne Switzerland., Obeid M; University Hospital of Lausanne Lausanne Switzerland., Chalkidis N; Scientific Research Consulting Hellas, Statistics Center, Athens, Greece. Athens Greece., Zoi T; Scientific Research Consulting Hellas, Statistics Center, Athens, Greece. Greece., Bisig B; University Hospital of Lausanne Lausanne, Vaud Switzerland., Trueb L; University Hospital of Lausanne Lausanne Switzerland., Gulhan DC; Harvard University Boston United States., Sempoux C; University Hospital of Lausanne Lausanne Switzerland., Dafni U; National and Kapodistrian University of Athens Athens, ATTIKI Greece., Tissot S; University Hospital of Lausanne Lausanne Switzerland., Coukos G; University Hospital of Lausanne Lausanne Switzerland., Herrera FG; University Hospital of Lausanne Lausanne Switzerland., Dangaj Laniti D; University Hospital of Lausanne Lausanne Switzerland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: Combinatorial delivery of low-dose radiotherapy and immunotherapy to patients with immune-excluded tumors enhances CD8+ T cell functionality.
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  Data: <searchLink fieldCode="AU" term="%22Ochoa-de-Olza+M%22">Ochoa-de-Olza M</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Rayroux+N%22">Rayroux N</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Imbimbo+M%22">Imbimbo M</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Orcurto+A%22">Orcurto A</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Fahr+N%22">Fahr N</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Benedetti+F%22">Benedetti F</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Dagher+J%22">Dagher J</searchLink>; University of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Spagnol+G%22">Spagnol G</searchLink>; University of Padua Padova Italy.<br /><searchLink fieldCode="AU" term="%22Barras+D%22">Barras D</searchLink>; University Hospital of Lausanne Lausanne, Vaud Switzerland.<br /><searchLink fieldCode="AU" term="%22Ghisoni+E%22">Ghisoni E</searchLink>; University of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Navarro+B%22">Navarro B</searchLink>; University Hospital of Lausanne Lausanne, Vaud Switzerland.<br /><searchLink fieldCode="AU" term="%22Mulvey+A%22">Mulvey A</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Berthold+D%22">Berthold D</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Sarivalasis+A%22">Sarivalasis A</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Zaman+K%22">Zaman K</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Stravodimou+A%22">Stravodimou A</searchLink>; Centre Hospitalier Universitaire Vaudois Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Digklia+A%22">Digklia A</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Duran+R%22">Duran R</searchLink>; University Hospital of Lausanne Lausanne, Vaud Switzerland.<br /><searchLink fieldCode="AU" term="%22Dromain+C%22">Dromain C</searchLink>; University Hospital of Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Prior+JO%22">Prior JO</searchLink>; University Hospital of Lausanne Lausanne, VD Switzerland.<br /><searchLink fieldCode="AU" term="%22Schaefer+N%22">Schaefer N</searchLink>; University Hospital of Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Zimmermann+S%22">Zimmermann S</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Obeid+M%22">Obeid M</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Chalkidis+N%22">Chalkidis N</searchLink>; Scientific Research Consulting Hellas, Statistics Center, Athens, Greece. Athens Greece.<br /><searchLink fieldCode="AU" term="%22Zoi+T%22">Zoi T</searchLink>; Scientific Research Consulting Hellas, Statistics Center, Athens, Greece. Greece.<br /><searchLink fieldCode="AU" term="%22Bisig+B%22">Bisig B</searchLink>; University Hospital of Lausanne Lausanne, Vaud Switzerland.<br /><searchLink fieldCode="AU" term="%22Trueb+L%22">Trueb L</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Gulhan+DC%22">Gulhan DC</searchLink>; Harvard University Boston United States.<br /><searchLink fieldCode="AU" term="%22Sempoux+C%22">Sempoux C</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Dafni+U%22">Dafni U</searchLink>; National and Kapodistrian University of Athens Athens, ATTIKI Greece.<br /><searchLink fieldCode="AU" term="%22Tissot+S%22">Tissot S</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Coukos+G%22">Coukos G</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Herrera+FG%22">Herrera FG</searchLink>; University Hospital of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Dangaj+Laniti+D%22">Dangaj Laniti D</searchLink>; University Hospital of Lausanne Lausanne Switzerland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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