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A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

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Title: A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.
Authors: Fang A; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Tang X; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Fleming M; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Tancowny B; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Wang X; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; School of Materials Science and Engineering, Harbin Institute of Technology, Weihai, Shandong, China., Wang Y; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, T2N 1N4, Canada., Daude N; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Dorosh L; Department of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada., Fleck SC; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada., Rathod V; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada., Coustou V; Institut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France., Cervantes SA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA., Velásquez CD; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2R3, Canada., Westaway D; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Aiken J; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 1C9, Canada., McKenzie D; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Telling G; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, 80523, USA., Stepanova M; Department of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada., Saupe SJ; Institut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France., Siemer AB; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA., Wille H; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada. wille@ualberta.ca.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada. wille@ualberta.ca.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada. wille@ualberta.ca.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Apr 17; Vol. 151 (1). Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.
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  Data: <searchLink fieldCode="AU" term="%22Fang+A%22">Fang A</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Fleming+M%22">Fleming M</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Tancowny+B%22">Tancowny B</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; School of Materials Science and Engineering, Harbin Institute of Technology, Weihai, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, T2N 1N4, Canada.<br /><searchLink fieldCode="AU" term="%22Daude+N%22">Daude N</searchLink>; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Dorosh+L%22">Dorosh L</searchLink>; Department of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.<br /><searchLink fieldCode="AU" term="%22Fleck+SC%22">Fleck SC</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.<br /><searchLink fieldCode="AU" term="%22Rathod+V%22">Rathod V</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada.<br /><searchLink fieldCode="AU" term="%22Coustou+V%22">Coustou V</searchLink>; Institut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Cervantes+SA%22">Cervantes SA</searchLink>; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Velásquez+CD%22">Velásquez CD</searchLink>; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2R3, Canada.<br /><searchLink fieldCode="AU" term="%22Westaway+D%22">Westaway D</searchLink>; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Aiken+J%22">Aiken J</searchLink>; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22McKenzie+D%22">McKenzie D</searchLink>; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada.; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2R3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Telling+G%22">Telling G</searchLink>; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, 80523, USA.<br /><searchLink fieldCode="AU" term="%22Stepanova+M%22">Stepanova M</searchLink>; Department of Electrical & Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.<br /><searchLink fieldCode="AU" term="%22Saupe+SJ%22">Saupe SJ</searchLink>; Institut de Biochimie et de Génétique Cellulaire, Centre National de La Recherche Scientifique, IBGC, UMR 5095, 33077, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Siemer+AB%22">Siemer AB</searchLink>; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Wille+H%22">Wille H</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada. wille@ualberta.ca.; Centre for Prions and Protein Folding Diseases, University of Alberta, 110C Brain and Aging Research Building (BARB), Edmonton, AB, T6G 2M8, Canada. wille@ualberta.ca.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada. wille@ualberta.ca.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 Apr 17; Vol. 151 (1). <i>Date of Electronic Publication: </i>2026 Apr 17.
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