Marrow-ablative chemotherapy and re-irradiation are associated with improved overall survival in patients with relapsed central nervous system nongerminomatous germ cell tumors.

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Title: Marrow-ablative chemotherapy and re-irradiation are associated with improved overall survival in patients with relapsed central nervous system nongerminomatous germ cell tumors.
Authors: Abu-Arja MH; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA. Mohammad.AbuArja@bcm.edu.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA. Mohammad.AbuArja@bcm.edu.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA. Mohammad.AbuArja@bcm.edu.; The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Mohammad.AbuArja@bcm.edu., Rajabi Z; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA.; Department of Internal Medicine, The University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA., McGlynn MC; The Division of Hematology, Oncology, and Blood and Marrow Transplantation, St. Louis Children's Hospital, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8116, St. Louis, MO, USA., Ghebrelul RT; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA., Zobeck M; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Harasis S; The University of Jordan Faculty of Medicine, Amman, Jordan., Arora J; Center for Biostatistics and Data Science, Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Zaghloul MS; Department of Radiation Oncology, National Cancer Institute, Cairo University, & Children Cancer Hospital of Egypt, Cairo, Egypt., Elhemaly A; Division of Pediatric Oncology, National Cancer Institute, Cairo University, and Children's Cancer Hospital of Egypt, Cairo, Egypt., Bertrand K; St Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; St Jude Children's Research Hospital, Memphis, TN, USA., Ronsley R; The Department of Pediatrics, Seattle Children's Hospital, and the University of Washington, Seattle, WA, USA., Cappellano AM; Pediatric Oncology, IOP-GRAACC/Federal University of São Paulo, São Paulo, Brazil., Dassi N; Pediatric Oncology, IOP-GRAACC/Federal University of São Paulo, São Paulo, Brazil., Czogala M; The Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland., Graham RT; The Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Knowles T; Department of Neurology, University of California, San Francisco, CA, USA., Mueller S; Department of Neurology, University of California, San Francisco, CA, USA.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland., Fisher MJ; Division of Oncology, The Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Finlay JL; Departments of Pediatrics and Radiation Oncology, The Ohio State University, College of Medicine, Columbus, OH, USA., Dhall G; The Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Nagabushan S; The Kids Cancer Centre, Sydney Children's Hospital and University of New South Wales, Randwick, New South Wales, Australia., Abdelbaki MS; The Division of Hematology, Oncology, and Blood and Marrow Transplantation, St. Louis Children's Hospital, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8116, St. Louis, MO, USA. mohameda@wustl.edu.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Apr 17; Vol. 177 (3). Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
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  Data: Marrow-ablative chemotherapy and re-irradiation are associated with improved overall survival in patients with relapsed central nervous system nongerminomatous germ cell tumors.
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  Data: <searchLink fieldCode="AU" term="%22Abu-Arja+MH%22">Abu-Arja MH</searchLink>; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA. Mohammad.AbuArja@bcm.edu.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA. Mohammad.AbuArja@bcm.edu.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA. Mohammad.AbuArja@bcm.edu.; The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Mohammad.AbuArja@bcm.edu.<br /><searchLink fieldCode="AU" term="%22Rajabi+Z%22">Rajabi Z</searchLink>; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA.; Department of Internal Medicine, The University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22McGlynn+MC%22">McGlynn MC</searchLink>; The Division of Hematology, Oncology, and Blood and Marrow Transplantation, St. Louis Children's Hospital, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8116, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Ghebrelul+RT%22">Ghebrelul RT</searchLink>; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zobeck+M%22">Zobeck M</searchLink>; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, 1102 Bates Ave, Houston, TX, 77030, USA.; Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, 1102 Bates Ave, Houston, TX, 77030, USA.; The Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Harasis+S%22">Harasis S</searchLink>; The University of Jordan Faculty of Medicine, Amman, Jordan.<br /><searchLink fieldCode="AU" term="%22Arora+J%22">Arora J</searchLink>; Center for Biostatistics and Data Science, Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zaghloul+MS%22">Zaghloul MS</searchLink>; Department of Radiation Oncology, National Cancer Institute, Cairo University, & Children Cancer Hospital of Egypt, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elhemaly+A%22">Elhemaly A</searchLink>; Division of Pediatric Oncology, National Cancer Institute, Cairo University, and Children's Cancer Hospital of Egypt, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Bertrand+K%22">Bertrand K</searchLink>; St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gajjar+A%22">Gajjar A</searchLink>; St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ronsley+R%22">Ronsley R</searchLink>; The Department of Pediatrics, Seattle Children's Hospital, and the University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cappellano+AM%22">Cappellano AM</searchLink>; Pediatric Oncology, IOP-GRAACC/Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Dassi+N%22">Dassi N</searchLink>; Pediatric Oncology, IOP-GRAACC/Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Czogala+M%22">Czogala M</searchLink>; The Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.<br /><searchLink fieldCode="AU" term="%22Graham+RT%22">Graham RT</searchLink>; The Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+T%22">Knowles T</searchLink>; Department of Neurology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Department of Neurology, University of California, San Francisco, CA, USA.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fisher+MJ%22">Fisher MJ</searchLink>; Division of Oncology, The Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Finlay+JL%22">Finlay JL</searchLink>; Departments of Pediatrics and Radiation Oncology, The Ohio State University, College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dhall+G%22">Dhall G</searchLink>; The Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Nagabushan+S%22">Nagabushan S</searchLink>; The Kids Cancer Centre, Sydney Children's Hospital and University of New South Wales, Randwick, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Abdelbaki+MS%22">Abdelbaki MS</searchLink>; The Division of Hematology, Oncology, and Blood and Marrow Transplantation, St. Louis Children's Hospital, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8116, St. Louis, MO, USA. mohameda@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%228309335%22">Journal of neuro-oncology</searchLink> [J Neurooncol] 2026 Apr 17; Vol. 177 (3). <i>Date of Electronic Publication: </i>2026 Apr 17.
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