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Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis.

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Title: Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis.
Authors: Wang H; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China; Innovation Center, Tonghua Dongbao Pharmaceutical Co., Ltd., Longemont International Building, 1018 Changning Road, Changning District, 200042, Shanghai, China., Liu WY; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China., Zhang F; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Chen W; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Hu J; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Cheng R; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Chen Z; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Wu D; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Xie L; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Tao Y; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and Xiangya School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China., Zheng MH; MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn., Hu F; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. Electronic address: hu_fang98@csu.edu.cn.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jul; Vol. 180, pp. 156622. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China; Innovation Center, Tonghua Dongbao Pharmaceutical Co., Ltd., Longemont International Building, 1018 Changning Road, Changning District, 200042, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+WY%22">Liu WY</searchLink>; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Cheng+R%22">Cheng R</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and Xiangya School of Basic Medicine, Central South University, Changsha, 410078, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+MH%22">Zheng MH</searchLink>; MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. Electronic address: hu_fang98@csu.edu.cn.
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        Value: 10.1016/j.metabol.2026.156622
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      – Code: eng
        Text: English
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      – TitleFull: Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis.
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              Text: 2026 Jul
              Type: published
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