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Confirmatory efficacy and safety trial of magnetic seizure therapy versus right unilateral ultra-brief electroconvulsive therapy in depression (CREST-MST): a randomised, double-blind, non-inferiority trial in Canada and the USA.

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Title: Confirmatory efficacy and safety trial of magnetic seizure therapy versus right unilateral ultra-brief electroconvulsive therapy in depression (CREST-MST): a randomised, double-blind, non-inferiority trial in Canada and the USA.
Authors: Blumberger DM; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: daniel.blumberger@camh.ca., McClintock SM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Perot Foundation Neuroscience Translational Research Center, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Thorpe KE; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Sick Children's Hospital, Toronto, ON, Canada., Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Foley K; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Toronto General Hospital, University Health Network, Toronto, ON, Canada., Husain MM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kaster TS; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Knyahnytska Y; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Queen's University, Kingston, ON, Canada., Voineskos D; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Bailey KJ; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hubregsen JJ; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Weissman CR; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Daskalakis ZJ; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Source: The lancet. Psychiatry [Lancet Psychiatry] 2026 May; Vol. 13 (5), pp. 376-386.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101638123 Publication Model: Print Cited Medium: Internet ISSN: 2215-0374 (Electronic) Linking ISSN: 22150366 NLM ISO Abbreviation: Lancet Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Confirmatory efficacy and safety trial of magnetic seizure therapy versus right unilateral ultra-brief electroconvulsive therapy in depression (CREST-MST): a randomised, double-blind, non-inferiority trial in Canada and the USA.
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  Data: <searchLink fieldCode="AU" term="%22Blumberger+DM%22">Blumberger DM</searchLink>; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: daniel.blumberger@camh.ca.<br /><searchLink fieldCode="AU" term="%22McClintock+SM%22">McClintock SM</searchLink>; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Perot Foundation Neuroscience Translational Research Center, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Thorpe+KE%22">Thorpe KE</searchLink>; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Sick Children's Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tamminga+CA%22">Tamminga CA</searchLink>; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Foley+K%22">Foley K</searchLink>; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Toronto General Hospital, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Husain+MM%22">Husain MM</searchLink>; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kaster+TS%22">Kaster TS</searchLink>; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Knyahnytska+Y%22">Knyahnytska Y</searchLink>; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Voineskos+D%22">Voineskos D</searchLink>; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bailey+KJ%22">Bailey KJ</searchLink>; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hubregsen+JJ%22">Hubregsen JJ</searchLink>; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+CR%22">Weissman CR</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Daskalakis+ZJ%22">Daskalakis ZJ</searchLink>; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
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              Text: 2026 May
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