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Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina: The ORBITA-CTO Trial.

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Title: Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina: The ORBITA-CTO Trial.
Authors: Khan S; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Sajjad U; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Fawaz S; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom., Butt H; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Simpson R; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Ibrahim A; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Robertson C; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom., Kelly P; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom., Mohdnazri SR; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom., Tang K; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom., Cook CM; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Demir OM; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., O'Kane P; Department of Interventional Cardiology, Royal Bournemouth Hospital, Bournemouth, United Kingdom., Spratt JC; Department of Interventional Cardiology, St George's Hospital, London, United Kingdom., Brilakis ES; Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA., Karamasis GV; School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Shun-Shin M; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Al-Lamee R; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Keeble TR; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom., Davies JR; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom. Electronic address: john.davies32@nhs.net.
Corporate Authors: ORBITA-CTO Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Mar 29. Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina: The ORBITA-CTO Trial.
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  Data: <searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sajjad+U%22">Sajjad U</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fawaz+S%22">Fawaz S</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Butt+H%22">Butt H</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simpson+R%22">Simpson R</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ibrahim+A%22">Ibrahim A</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Robertson+C%22">Robertson C</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kelly+P%22">Kelly P</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mohdnazri+SR%22">Mohdnazri SR</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tang+K%22">Tang K</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cook+CM%22">Cook CM</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Demir+OM%22">Demir OM</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Kane+P%22">O'Kane P</searchLink>; Department of Interventional Cardiology, Royal Bournemouth Hospital, Bournemouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Spratt+JC%22">Spratt JC</searchLink>; Department of Interventional Cardiology, St George's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brilakis+ES%22">Brilakis ES</searchLink>; Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Karamasis+GV%22">Karamasis GV</searchLink>; School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Shun-Shin+M%22">Shun-Shin M</searchLink>; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Al-Lamee+R%22">Al-Lamee R</searchLink>; National Heart and Lung Institute, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Keeble+TR%22">Keeble TR</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davies+JR%22">Davies JR</searchLink>; Department of Interventional Cardiology, Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Essex, United Kingdom; Anglia Ruskin University School of Medicine and MTRC, Chelmsford, Essex, United Kingdom. Electronic address: john.davies32@nhs.net.
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